Non-syndromic odontogenic keratocysts: A rare case report

Kurdekar, Raghavendra S; Prakash, Jeevan; Rana, A S; Kalra, Puneet

doi:10.4103/0975-5950.117874

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…Histologically most cases of OKCs (61%) were lined by parakeratinised epithelium which is similar to the findings of most of the studies conducted in different countries. 13,14 Epithelial hyperplasia was observed in 38.5% OKCs in the present study which is consistent with a study conducted on the Brazilian population. 15 Spongiosis was observed in 46% OKCs in the present study but no data is available in the literature regarding spongiosis in OKCs.…”

Section: Discussionsupporting

confidence: 92%

Immunohistochemical expression of ki-67 in odontogenic keratocyst: Evidence of aggressive behavior.

Saif

Jehangir²,

Nagi

et al. 2020

TPMJ

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The odontogenic keratocyst (OKC) well-known for its aggressiveness and high recurrence rate, comprises approximately 11% of all jaw cysts. Due to its aggressive behavior it was placed into category of tumour in 2005 by the World Health Organization (WHO). Objectives: The purpose of this study was to determine the Ki-67 expression in Odontogenic Keratocysts to predict its proliferative potential. Study Design: Descriptive study. Setting: Department of Morbid Anatomy and Histopathology, UHS. Periods: June 2014- June 2018. Material & Methods: This is a descriptive study comprising of 39 cases of odontogenic cysts. These surgically removed samples were processed at University of Health Sciences (UHS) laboratory. Routine staining with Hematoxylin & Eosin stain along with immunohistochemistry (IHC) with Ki-67 antibody was performed. Immunohisto chemical scoring was done on the basis of percentage of the nuclear staining of Ki-67. Data was entered into SPSS 22 and descriptive statistics were measured in the form of percentage and frequency. Quantitative variables such as age of patient, size of the cyst, and Ki-67 score were also measured. P value <0.05 was taken as significant. Results: The mean age of the patients was 25.08 ±14.5 years. Significant association was observed between histological variables with odontogenic keratocyst such as parakeratinized epithelial lining (p = 0.00), epithelial hyperplasia both typical and atypical (p = 0.02) and focal spongiosis (p = 0.04). Foci having epithelial atypia demonstrated stronger staining intensity compared to adjacent normal epithelium. However, no significant association was observed between the histological variables and Ki-67 expression. Conclusion: OKC expressed low Ki-67 expression in most of the cases, however, foci of strong expression were also observed in few cases.

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Section: Discussionsupporting

confidence: 92%

Immunohistochemical expression of ki-67 in odontogenic keratocyst: Evidence of aggressive behavior.

Saif

Jehangir²,

Nagi

et al. 2020

TPMJ

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“…The review of case reports of this condition showed that the non-syndromic type often affects the individual at early decades of life, mainly the second decade, with the mandible and maxilla being the most common sites of involvement, as in line with the present findings. Kurdekar [10] and Bartake [11] found the maxilla to be the target area of non-syndromic keratocysts, which is inconsistent with this case report. Swelling, pain, drainage and discharge of pus and delays in tooth eruption have been reported as the causes of presenting with non-syndromic multiple keratocysts.…”

Section: Discussioncontrasting

confidence: 94%

“…Swelling, pain, drainage and discharge of pus and delays in tooth eruption have been reported as the causes of presenting with non-syndromic multiple keratocysts. The present case report is consistent with the results obtained by Bartake [11] , Kurdekar [10] and Auluk et al [3] in terms of the symptoms of involvement, but inconsistent with the results obtained by Parikh [12] .…”

Section: Discussionsupporting

confidence: 72%

Non-syndromic multiple keratocystic odontogenic tumor: A case report

Sohanian

Seifi

Dezfouli

et al. 2017

JOA

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A Keratocystic Odontogenic Tumor (KCOT) is a benign odontogenic lesion that is well-known for its histopathological features and invasive clinical behaviors. KCOTs may be non-syndromic or syndromic, and the syndromic type presents a higher risk of recurrence and invasive behaviors. Non-syndromic KCOTs are uncommon and account for only 5% of the cases. The purpose of the present case report is to conduct clinical, radiographic and pathologic evaluations and treat a 37-year-old man with non-syndromic nevoid basal cell carcinoma. Syndromic and non-syndromic keratocysts present more invasive behaviors than the solitary type.The initial symptoms of syndromic keratocysts appear as multiple keratocysts of the mandible and maxilla that are diagnosed by a dentist; as a result, the diagnosis and treatment of the disease is very crucial.

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“…2 A partial expression of the PTCH gene may result in the occurrence of only multiple recurring OKCs, without any associated systemic findings. 3 The term 'multiple' refers to the lifetime history of the patient and not to many cysts present at any one time. Any patient with more than 1 OKC other than a recurrence is generally said to show some other features of the syndrome, albeit only minor anomalies, which may be revealed only during full examination.…”

Section: Introductionmentioning

confidence: 99%

Tetrad presentation of non-syndromic odontogenic keratocyst: An uphill diagnostic and therapeutic challenge

Marimuthu

Shetty

2018

Dent. Med. Probl.

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Odontogenic keratocyst (OKC), in the last decade sceptically referred to as keratocystic odontogenic tumor (KCOT), is known for its subclinical extensive growth potential and significant rate of recurrences. Odontogenic keratocyst, being the third most common cystic lesion (10-20%) of the maxillofacial region, is often recognized as a sporadic lesion and is well-documented in the literature. Multiple presentation of these cysts over a lifetime is relatively uncommon and is usually seen in conjunction with nevoid basal cell carcinoma syndrome (NBCC), orofacial digital syndrome, Noonan syndrome, Ehlers-Danlos syndrome, Simpson-Golabi-Behmel syndrome, or other syndromes. The 'two-hit' hypothesis postulated by Knudson best explains this anomaly, wherein multiple OKCs associated with the syndromes arise as a consequence of the allelic loss in the patched (PTCH) gene, mapped to the long arm of chromosome 9q22.3-q31. A partial expression of the gene may result in multiple OKCs (5%) without any related syndromes. Though concurrent occurrence of non-syndromic multiple OKCs is a rare phenomenon, a handful of cases have been documented over the past few years. Adding to this, we report a case of multiple OKCs occurring synchronously and bilaterally in all 4 quadrants in non-syndromic, otherwise healthy persons, which could indicate a shift in trend.

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Non-syndromic odontogenic keratocysts: A rare case report

Cited by 10 publications

References 21 publications

Immunohistochemical expression of ki-67 in odontogenic keratocyst: Evidence of aggressive behavior.

Immunohistochemical expression of ki-67 in odontogenic keratocyst: Evidence of aggressive behavior.

Non-syndromic multiple keratocystic odontogenic tumor: A case report

Tetrad presentation of non-syndromic odontogenic keratocyst: An uphill diagnostic and therapeutic challenge

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