Non-syndromic cleft lip and palate: Could stress be a causal factor?

Wallace, G; Arellano, Jacinta M; Gruner, Tini M

doi:10.1016/j.wombi.2010.08.001

Cited by 21 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 1 They have geographic and racial variations 2 and seem to occur as a result of a complex interaction between genetic variations and environmental factors. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 …”

Section: Introductionmentioning

confidence: 99%

Environmental factors related to the occurrence of oral clefts in a Brazilian subpopulation

et al. 2016

View full text Add to dashboard Cite

Background:A cross-sectional study was conducted at the Craniofacial Rehabilitation Center in the General Hospital of the University of Cuiabá, Cuiabá city, Mato Grosso, Brazil.Materials and Methods:Poisson regression model was used to analyze the relationship between antenatal factors and the occurrence of oral clefts in 116 patients.Results:Oral clefts were more common in males (64.66%) and White race (46.02%). The mean age of the children was 21.91 months. The most common type of cleft was cleft lip and palate (CLP, 55.17%). Maternal and paternal smoking in the first trimester of pregnancy and parity were significantly associated with the occurrence of CLP. Parent's age, educational level, and occupation did not interfere in the occurrence of oral clefts. There was also no significant association between maternal illness, medication use, alcohol consumption, and maternal exposure to chemicals in the first trimester of pregnancy and the occurrence of clefts in this population.Conclusion:The analysis of the environmental factors present during the pregnancy of children with oral clefts revealed a significant association between parity (second onward), maternal smoking, and paternal smoking and the occurrence of CL and/or palate in this population.

show abstract

Section: Introductionmentioning

confidence: 99%

Environmental factors related to the occurrence of oral clefts in a Brazilian subpopulation

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Heightened levels of maternal psychological stress may be implicated in the etiology of clefting (Wallace , 2011). However, the differences in stress measurements and a lack of consensus on the definition of maternal stress are reasons that only a small number of researchers are considering the presence of stressful life events during pregnancy as a risk factor in NCL/P occurrence (Fraser and Warburton, 1964;Montenegro et al, 1995;Carmichael and Shaw, 2000;Rajabian and Sherkat, 2000;Carmichael et al, 2007;Cottrell and Seckl et al, 2009;Wallace et al, 2011). Moreover, the influence of environmental and genetic factors on each individual's variability in the stress response create additional challenges when investigating the mental or emotional stress as a causal factor for NCL/P.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, there are a number of reports showing that maternal genetic and nutritional factors can also be implicated in the etiology of this birth anomaly (Krapels et al, 2006). Heightened maternal psychological stress immediately before or at an early stage in the pregnancy appears to be involved as a risk factor in the occurrence of clefting as well (Carmichael et al, 2007;Wallace et al, 2011). Hansen et al (2000) showed that women exposed to the unexpected death of an older child during the first trimester of pregnancy had an eightfold increased risk of cranial-neural-crest malformations, including orofacial clefts, in their offspring.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of stress‐related genes and the risk of nonsyndromic cleft lip with or without cleft palate

Mostowska

Hozyasz²,

Wójcicka

et al. 2011

Birth Defects Research

View full text Add to dashboard Cite

show abstract

“…Nonsyndromic cleft lip with or without palate (NSCLP) is a malformation without any other signs or symptoms of atypical condition such as abnormal physical appearance or psychological disease (Wallace, Arellano, & Gruner, 2011). Cleft lip and/or palate are one of the most common human embryonic disorder reported in Western countries and the second most common birth deformities among the babies (Muhamad & Azzaldeen, 2012;Shaw, Croen, & Curry, 1991).…”

Section: Introductionmentioning

confidence: 99%

Two novel genes TOX3 and COL21A1 in large extended Malay families with nonsyndromic cleft lip and/or palate

Shah

Sulong

Sulaiman

et al. 2019

Molec Gen & Gen Med

View full text Add to dashboard Cite

Background Nonsyndromic cleft lip and/or palate is one of the most common human birth defects worldwide that affects the lip and/or palate. The incidence of clefts varies among populations through ethnic, race, or geographical differences. The focus on Malay nonsyndromic cleft lip and/or palate (NSCL/P) is because of a scarce report on genetic study in relation to this deformity in Malaysia. We are interested to discuss about the genes that are susceptible to cause orofacial cleft formation in the family. Methods Genome‐wide linkage analysis was carried out on eight large extended families of NSCL/P with the total of 91 individuals among Malay population using microarray platform. Based on linkage analyses findings, copy number variation (CNV) of LPHN2 , SATB2 , PVRL3 , COL21A1, and TOX3 were identified in four large extended families that showed linkage evidence using quantitative polymerase chain reaction (qPCR) as for a validation purpose. Copy number calculated (CNC) for each genes were determined with Applied Biosystems CopyCallerTM Software v2.0. Normal CNC of the target sequence expected was set at two. Results Genome‐wide linkage analysis had discovered several genes including TOX3 and COL21A1 in four different loci 4p15.2‐p16.1, 6p11.2‐p12.3, 14q13‐q21, and 16q12.1. There was significant decreased, p < 0.05 of SATB2 , COL21A1, and TOX3 copy number in extended families compared to the normal controls. Conclusion Novel linkage evidence and significant low copy number of COL21A1 and TOX3 in NSCLP family was confirmed. These genes increased the risks toward NSCLP formation in that family traits.

show abstract

Non-syndromic cleft lip and palate: Could stress be a causal factor?

Cited by 21 publications

References 20 publications

Environmental factors related to the occurrence of oral clefts in a Brazilian subpopulation

Environmental factors related to the occurrence of oral clefts in a Brazilian subpopulation

Polymorphisms of stress‐related genes and the risk of nonsyndromic cleft lip with or without cleft palate

Two novel genes TOX3 and COL21A1 in large extended Malay families with nonsyndromic cleft lip and/or palate

Contact Info

Product

Resources

About