Non-susceptibility trends among Pseudomonas aeruginosa and other non-fermentative Gram-negative bacteria from bacteraemias in the UK and Ireland, 2001-06

Livermore, David M.; Hope, Russell; Brick, Geraldine; Lillie, Mark; Reynolds, Rosy

doi:10.1093/jac/dkn352

Cited by 47 publications

(36 citation statements)

References 22 publications

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“…This result is in agreement with published data from large multi-center collaborations [43,44]. Resistance to standard antipseudomonal agents was observed to increase with increasing contact with the healthcare system.…”

Section: Factorsupporting

confidence: 92%

Population-Based Study of the Epidemiology and the Risk Factors for Pseudomonas aeruginosa Bloodstream Infection

et al. 2009

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Section: Factorsupporting

confidence: 92%

Population-Based Study of the Epidemiology and the Risk Factors for Pseudomonas aeruginosa Bloodstream Infection

et al. 2009

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“…Thus, attention should be paid to Acb complex colonization or infection in these cases. Strains of drug- Other investigators showed that bacterial sensitivity to carbapenems has dramatically decreased in recent years (11,18). In contrast, the present study revealed that most of the 201 isolates were sensitive to antibiotics, particularly carbapenems.…”

Section: Discussioncontrasting

confidence: 62%

Clinical Characteristics of Tertiary Hospital Patients from Whom Acinetobacter calcoaceticus-Acinetobacter baumannii Complex Strains were Isolated

et al. 2012

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Objective Acinetobacter baumannii is a worldwide nosocomial pathogen that has become increasingly common over the past few decades, and strains of multidrug-resistant A. baumannii have been increasing. The aim of this study was to assess the clinical characteristics of A. calcoaceticus-A. baumannii complex (Acb complex) strains and to determine the risk factors of this infection. Methods The medical records of 121 patients at Nagasaki University Hospital from whom Acb complex had been isolated between January 2007 and December 2009 were retrospectively reviewed. Patient backgrounds, sensitivity to antibiotics, risk factors for infection, and prognosis were evaluated. Results Lower respiratory isolates accounted for 73% (147 strains) of all 201 isolates. Most of the isolates were sensitive to carbapenems. Of the 121 patients (74 males and 47 females; mean age: 62.1 years), 48 (39.7%) had malignancy and 75 (62.0%) were treated with antibiotics prior to isolation. Thirty-seven of the patients in this study (30.6%) were infected by Acb complex and the most frequent clinical manifestation was pneumonia (18 cases; 48.6%). Approximately 60% of infected patients were treated with β-lactam agent in combination with β-lactamase inhibitors or carbapenems. The mortality rate of infected patients was significantly higher than that of colonized patients (infected: 24.3%, colonized: 6.0%, p<0.05). Risk factors for Acb complex infection include being over 60 years of age, chronic liver disease, and the use of firstgeneration cephalosporins prior to isolation. Conclusion Acb complex was relatively sensitive to antibiotics. The appropriate usage of antibiotics should be continued for the prevention of drug resistance in Acb complex.

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“…Gram-negative bacterial resistance is of particular importance as there is a dearth of novel antibiotics directed against these organisms (1), which are increasing in prevalence worldwide (8,12,15). Logically, an association should exist between antibiotic consumption and Gram-negative bacterial resistance, and this was demonstrated in multiple studies in both the hospital and community settings (2,7,10,13,18).…”

mentioning

confidence: 99%

Surveillance and Correlation of Antibiotic Prescription and Resistance of Gram-Negative Bacteria in Singaporean Hospitals

Hsu

Tan

Tam

et al. 2010

Antimicrob Agents Chemother

114

108

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Non-susceptibility trends among Pseudomonas aeruginosa and other non-fermentative Gram-negative bacteria from bacteraemias in the UK and Ireland, 2001-06

Abstract: Most P. aeruginosa from bacteraemias in the UK and Ireland remain relatively susceptible by international standards; in contrast, multiresistance is widespread in Acb, with imipenem non-susceptibility emerging.

Cited by 47 publications

References 22 publications

Population-Based Study of the Epidemiology and the Risk Factors for Pseudomonas aeruginosa Bloodstream Infection

Population-Based Study of the Epidemiology and the Risk Factors for Pseudomonas aeruginosa Bloodstream Infection

Clinical Characteristics of Tertiary Hospital Patients from Whom Acinetobacter calcoaceticus-Acinetobacter baumannii Complex Strains were Isolated

Surveillance and Correlation of Antibiotic Prescription and Resistance of Gram-Negative Bacteria in Singaporean Hospitals

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