Non surgical therapy for anal fissure

Nelson, Richard L.

doi:10.1002/14651858.cd003431

Cited by 87 publications

(144 citation statements)

References 32 publications

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“…In a Cochrane Review of 53 randomized controlled trials (RCTs) of nonsurgical therapies for anal fissures and 15 RCTs that specifically looked at GTN versus placebo, GTN was found to be marginally but significantly better than placebo in healing anal fissures (49% vs 37%, p<0.004). [29] However, late recurrence was shown to be common (>50%) in those initially cured. In addition, dose made no difference in healing of anal fissures in three studies that compared doses of GTN ranging from 0.05% to 0.4% GTN.…”

Section: Topical Nitratesmentioning

confidence: 99%

Anal Fissure Revisited : A Systematic Review

Singh¹,

Chandrakar²,

Agrawal³

et al. 2015

jemds

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Anal fissure is one of the most common anorectal problems. Anal fissure is largely associated with high anal sphincter pressures and most treatment options are based on reducing anal pressures. There are many options to treat chronic fissures in ano. Some of them are non-surgical while the others are surgical. The efficacy claimed by each of the prevalent method is very high but the inconsistencies and contraindications are equally strong. To date, lateral sphincterotomy has been favoured by most of the proctologists, because it is the least extensive surgical procedure and is offering a long lasting relief in sphincter spasm. Various management technique are reviewed in this article along with Advancement flap for anterior fissure and a new method combining the age-old technique of Lord's manual dilatation followed by radio surgery is also highlighted along with their complications. The addition of radio surgery is found useful for refreshing the edges of the fissure and to tackle pathologies namely sentinel pile, small internal piles or hypertrophied anal papillae often found associated with chronic fissures. Revisiting the trends of treatment of chronic anal fissures, the most preferred options are the manual dilatation with radio surgery and the subcutaneous lateral anal sphincterotomy. Both methods are easy to perform, have negligible complications and no special setup is needed, except the radio surgical unit, in case of the first procedure.

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Section: Topical Nitratesmentioning

confidence: 99%

Anal Fissure Revisited : A Systematic Review

Singh¹,

Chandrakar²,

Agrawal³

et al. 2015

jemds

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“…Chronic wounds are pervasive worldwide, affecting more than 70 million people particularly in the senior population with harsh medical and social consequences. 15 In particular, diabetic foot ulcer affects 15% of people with diabetes and is the leading cause of nontraumatic amputation. 16 Denervation of local sympathetic nerve system is a hallmark of diabetic neuropathy and results in sensory deficits, so that the patients cannot respond to external stimuli such as pressure and heat.…”

Section: Diabetic Chronic Woundsmentioning

confidence: 99%

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Xiao

Ahadian

Radišić

2017

Tissue Engineering Part B: Reviews

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Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.

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“…BoNT/A wurde bei Analfissuren angewendet (Gui et al, 1994;Nelson, 2003;Tranqui et al, 2006), beim Stuhldrang, chronischer Obstipation (Baig et al, 2005;Bosshard et al, 2004;Maria et al, 2000), bei der Hirschsprung`schen Erkrankung (Langer and Birnbaum, 1997) und rektalem Schmerz (Jarvis et al, 2004 …”

Section: Anorekatale Erkrankungenunclassified

Botulinumtoxin in der Urologie

Schulte-Baukloh

Knispel

2004

Urologe [A]

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Non surgical therapy for anal fissure

Cited by 87 publications

References 32 publications

Anal Fissure Revisited : A Systematic Review

Anal Fissure Revisited : A Systematic Review

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Botulinumtoxin in der Urologie

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