Non-surgical management of chronic periodontitis with two local drug delivery agents-A comparative study

Abstract

Background: The selective removal or inhibition of pathogenic microbes with locally delivered antimicrobials when combined with scaling and root planing is often an effective approach for the managment of chronic periodontitis. Aim: To compare the clinical efficacy of tetracycline fibers and a xanthan based chlorhexidine gel in the treatment of chronic periodontitis. Methods and materials: Thirty systemically healthy patients in the age group of 30-50 years suffering from generalized chronic moderate periodontitis were selected. For each subject, two experimental sites were chosen that had probing depth >5mm and were located in symmetric quadrants and the sites were randomized at split mouth level with one receiving tetracycline fibers and the other chlorhexidine gel. Plaque score, bleeding score, probing pocket depth and relative attachment level gain was recorded on day 0 and at the end of 3 months. Results and conclusion: In both groups, there was statistically highly significant reduction in all the clinical parameters i.e. plaque score, bleeding score and probing pocket depth and relative attachment level gain was seen at different time intervals. Local delivery of tetracycline and chlorhexidine is a safe, easy and efficacious method along with scaling and root planing in the treatment of chronic periodontitis. Inter-comparison of both local drug delivery agents with respect to clinical changes shows that tetracycline fibers are better than chlorhexidine gel for treatment of chronic periodontitis. Nevertheless, long term studies with more samples are suggested to further evaluate and compare the efficacy of both materials.

Clinical evaluation of the efficacy of two commercially available controlled-release drugs-chlorhexidine gel (CHLO-SITE)™ and tetracycline fibers (periodontal plus AB)™ as an adjunct to scaling root planning in the treatment of chronic periodontitis

“…This reduction in supragingival plaque score could be attributed to chemical control of subgingival plaque by tetracycline fibers, which could also have an inhibitory effect on supragingival plaque. [23] Similar observations were made by Friesen et al, (2002). [11] Significant reduction in PI reduction was seen in chlorhexidine group and control group at 1 month and 3 months.…”

Professionally Delivered Local Antimicrobials in the Treatment of Patients with Periodontitis—A Narrative Review

“…Various studies have reported that local treatment with Periodontal Plus AB showed significant gain in CAL and reduction in probing depths compared to the control group [23][24][25][26]. The inter-comparison of clinical efficacy between TET-fibres and a xanthan based CHX gel (Chlosite ® ) showed that TET-fibres were better (they had significant gain in CAL and reduction in probing depths) than CHX gel [27]. More favourable outcome in both the clinical and biochemical variables when SRD was combined with LDD of TET fibres -reduction in the Alpha-2-macroglobulin levels in GCF.…”

Silver Nanoparticles in Dental Cure: Scenario and Confronts

“…Although, an additional clinical benefit of adjuvant Page: 66 systemic antibiotics has been described, it is only recommended in cases of refractory or aggressive periodontics to prevent the development of antimicrobial resistance [35]. In earlier studies, it has been reported that the local delivery of adjuvant antimicrobial therapy is considered a safe and effective alternative to systemic administration [36,37,38]. In one of the studies, a non-surgical approach using the repeated intrasulcular application of tetracycline films and AgNPs was used.…”