2013
DOI: 10.4103/0976-6944.119934
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Non-surgical endodontic treatment of extraoral sinus with triple antibiotic paste and mineral trioxide aggregate obturation

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“…Metronidazole was chosen as the first choice among the antibacterial drugs as obligate anaerobes are found in the deep layers of the infected dentine of the root canal wall. According to study, it has been demonstrated that metronidazole can penetrate the deep layers of carious lesions and disinfect the lesions in vivo and diffuse throughout the dentine 31 32. As the root canal with a periradicular lesion consists of complex nature of bacterial flora, metronidazole alone cannot kill all bacteria necessitating the need for other drugs to sterilise the infected root dentine.…”
Section: Discussionmentioning
confidence: 99%
“…Metronidazole was chosen as the first choice among the antibacterial drugs as obligate anaerobes are found in the deep layers of the infected dentine of the root canal wall. According to study, it has been demonstrated that metronidazole can penetrate the deep layers of carious lesions and disinfect the lesions in vivo and diffuse throughout the dentine 31 32. As the root canal with a periradicular lesion consists of complex nature of bacterial flora, metronidazole alone cannot kill all bacteria necessitating the need for other drugs to sterilise the infected root dentine.…”
Section: Discussionmentioning
confidence: 99%