Non-surgical ablative therapies for inoperable benign insulinoma

Mele, Chiara; Brunani, Amelia; Damascelli, B; Tichà, Vladimira; Castello, Luigi Mario; Aimaretti, Gianluca; Scacchi, Massimo; Marzullo, Paolo

doi:10.1007/s40618-017-0738-3

Cited by 24 publications

(15 citation statements)

References 50 publications

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“…TAE is an effective procedure which is recommended for patients who are not eligible for or refuse surgery. Post-procedure complications of TAE including abdominal pain, mild pancreatitis and transitory mild diabetes were observed [15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Treatment of insulinomas by laparoscopic radiofrequency ablation: case reports and literature review

Yao

Wang²,

Zhang³

et al. 2020

Open Medicine

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AbstractDespite its rarity, insulinoma is the most common type of pancreatic endocrine neoplasm, with an occurrence of 1 to 5 per million per year in the population. Surgical resection or enucleation is the first line of curative treatment choice for insulinoma. Eight patients with symptomatic insulinomas treated by radiofrequency ablation have been described since 2009. In the past two years, we treated two patients with symptomatic insulinomas (one in the pancreatic tail and the other in the pancreatic neck) successfully using laparoscopic radiofrequency ablation. Both patients achieved complete elimination without any significant complications. Our study suggests laparoscopic radiofrequency ablation could be developed as a safe and effective alternative treatment to surgery for the patients with insulinomas who refuse or are not eligible for surgery.

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Section: Discussionmentioning

confidence: 99%

Treatment of insulinomas by laparoscopic radiofrequency ablation: case reports and literature review

Yao

Wang²,

Zhang³

et al. 2020

Open Medicine

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“…In the context of MEN1, insulinomas are the second most prevalent functioning pancreatic tumor. They are characterized by hypoglycemia and the typical Whipple's triad, which is the first clinical manifestation of MEN1 syndrome in about 10% of subjects (36,53). MEN1 insulinomas usually manifest as single benign lesions (54), often sized >1 cm, in the setting of multiple islet macroadenomas (55).…”

Section: Gep-nets Tumorsmentioning

confidence: 99%

Phenotypes Associated With MEN1 Syndrome: A Focus on Genotype-Phenotype Correlations

et al. 2020

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“…Occasionally, a hypervascular pancreatic tumor corresponding to the insulinoma is visualized angiographically during the procedure ( Figure 6 ). In such cases, the tumor might be amenable to catheter-based embolic therapy or pre-operative methylene blue injection for improved surgical localization [ 12 , 59 ].…”

Section: Selective Arterial Calcium Stimulation and Hepatic Venousmentioning

confidence: 99%

“…Non-surgical techniques, such as transcatheter embolization, ethanol ablation, and radiofrequency ablation, are not yet well-established. Of these, ethanol ablation by endoscopic ultrasound (EUS) guidance is the most reported and achieves symptomatic relief in 85% of cases [ 12 ]. Medical options for symptomatic management in patients who are not surgical candidates include diazoxide and octreotide, both of which decrease insulin secretion.…”

Section: Introductionmentioning

confidence: 99%

Essentials of Insulinoma Localization with Selective Arterial Calcium Stimulation and Hepatic Venous Sampling

Zhao

Patel

Kulkarni

et al. 2020

JCM

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Insulinomas are the most common functional pancreatic neuroendocrine tumor. Most insulinomas can be localized non-invasively with cross-sectional and nuclear imaging. Selective arterial calcium stimulation and hepatic venous sampling is an effective and safe minimally-invasive procedure for insulinoma localization that may be utilized when non-invasive techniques are inconclusive. The procedure’s technical success and proper interpretation of its results is dependent on the interventional radiologist’s knowledge of normal and variant pancreatic arterial perfusion. Accurate pre-operative localization aids in successful surgical resection. Technical and anatomic considerations of insulinoma localization with selective arterial calcium stimulation and hepatic venous sampling are reviewed.

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Non-surgical ablative therapies for inoperable benign insulinoma

Abstract: Non-surgical ablation is a feasible, safe and repeatable procedure in patients with pancreatic insulinoma, who are not candidate to surgery or refuse it. Partial or complete control of symptoms and tumor growth is experienced by the majority of patients.

Cited by 24 publications

References 50 publications

Treatment of insulinomas by laparoscopic radiofrequency ablation: case reports and literature review

Treatment of insulinomas by laparoscopic radiofrequency ablation: case reports and literature review

Phenotypes Associated With MEN1 Syndrome: A Focus on Genotype-Phenotype Correlations

Essentials of Insulinoma Localization with Selective Arterial Calcium Stimulation and Hepatic Venous Sampling

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