Non-steroidal anti-inflammatory drugs may modulate the protease activity of Candida albicans

Carvalho, Alessandra P.; Gursky, Lauren Christine; Rosa, Rosimeire Takaki; Rymovicz, Alinne Ulbrich Mores; Campelo, Patrícia Maria Stuelp; Grégio, Ana Maria Trindade; Koga-Ito, Cristiane Yumi; Samaranayake, LP; Rosa, Edvaldo Antônio Ribeiro

doi:10.1016/j.micpath.2010.07.007

Cited by 19 publications

(14 citation statements)

References 46 publications

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“…Fungi (unlike bacteria and viruses) produce prostaglandins, and although their exact function is uncertain, it is thought that they influence virulence, in particular controlling the yeast-to-hypha transition and biofilm production (32,34,81). Aside from prostaglandin inhibition, as detailed in this review, other mechanisms by which antipyretic drugs influence pathogens include inhibiting virus replication (75)(76)(77)(78)(79), inhibiting or promoting bacterial and fungal growth (1-3, 5-9, 16-21, 34, 45, 52, 82-85), altering the expression of virulence factors (5,6,9,29,30,37,39,(43)(44)(45), changing the surface hydrophobicity of microbes (9), influencing biofilm production (16,21,30,32,33,35,(37)(38)(39)(40)(41), affecting motility (22,23), adherence (9,16,(25)(26)(27)(28)(29)(30)(31), and metabolism (16,18,46), interacting with the transport and release of antibiotics by PMNL …”

Section: Discussionmentioning

confidence: 99%

“…SAL at therapeutic levels decreases biofilm production by Candida spp. (21,(32)(33)(34), E. coli (25,26,35,36), P. aeruginosa (37)(38)(39), and S. epidermidis (Table 2) (30,38,40). Biofilm production by Salmonella enterica serovar Typhimurium was also reduced by SAL, but the concentrations tested were not specified (41).…”

mentioning

confidence: 99%

“…While one study reports that ibuprofen and acetaminophen at therapeutic levels enhance biofilm production in C. albicans by inducing the secretion of aspartylproteases (21), another study shows a reduction in biofilm production by Candida spp. after exposure to ibuprofen and diclofenac at levels above therapeutic concentrations (32).…”

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confidence: 99%

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Antimicrobial Effects of Antipyretics

Zimmermann

Curtis

2017

Antimicrob Agents Chemother

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Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote bacterial or fungal growth, alter the expression of virulence factors, change the surface hydrophobicity of microbes, influence biofilm production, affect the motility, adherence, and metabolism of pathogens, interact with the transport and release of antibiotics by leukocytes, modify the susceptibility of bacteria to antibiotics, and induce or reduce the frequency of mutations leading to antimicrobial resistance. While antipyretics may compromise the efficacy of antimicrobial therapy, they can also be beneficial, for example, in the management of biofilm-associated infections, in reducing virulence factors, in therapy of resistant pathogens, and in inducing synergistic effects. In an era where it is becoming increasingly difficult to find new antimicrobial drugs, targeting virulence factors, enhancing the efficacy of antimicrobial therapy, and reducing resistance may be important strategies.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Antimicrobial Effects of Antipyretics

Zimmermann

Curtis

2017

Antimicrob Agents Chemother

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“…Supernatants were combined with equal volumes of 1 M NaOH and the OD 440 nm were measured. One enzymatic activity unity was arbitrarily defined as the amount of enzyme that increments OD 440 nm in 0.001 unity of absorbance per min of digestion 15 . The proportional enzymatic activities were estimated as the enzymatic unities per reduced XTT absorbances 14 .…”

Section: Planktonic Growthmentioning

confidence: 99%

Modulatory Effects of Dexamethasone upon Virulence Attributes of Pseudomonas Aeruginosa ATCC® 27853™

Ferreir¹,

Gregi²,

Alani³

et al. 2015

Insight Microbiology

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Background: Pseudomonas aeruginosa is a versatile and opportunistic human pathogen whose virulence derives from several factors as extracellular proteases, pyocyanin and pyoverdin and biofilm formation, among others. Dexamethasone is a glucocorticoid widely used as anti-inflammatory. Despite its immunosuppressive role, the interplay between dexamethasone and bacterial virulence remains uncovered. Objectives: In this study, the dexamethasone modulatory effects on planktonic growth, surface adhesion, cell surface hydrophobicity, biofilm formation and pyocyanin and protease secretion by P. aeruginosa ATCC®27853TM was evaluated. Results and Conclusion: The results showed that dexamethasone decreases planktonic cell growth rate and biofilm development. In other hand, the medicine increases proportional pyocyanin secretion and, in high concentrations, collaborates with the bacterial adherence.

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“…28 Non-steroidal anti-inflammatory drugs (NSAIDS) modulate its activity. 29 cs Seems to cleave APP successively at different positions: e49, t46 and then g42, g40 and g38. APP can form dimers through dimerization motifs GxxxG.…”

Section: Presenilinsmentioning

confidence: 99%

Interdisciplinary challenges and promising theranostic effects of nanoscience in Alzheimer's disease

et al. 2012

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During the last decade, reports show that the incidence and prevalence of Alzheimer's disease (AD) and other dementias have significantly increased. AD poses an enormous escalating threat to health services and resources. Early diagnosis of AD is recognized as one of the major challenges and primary aims in scientific communities. With the arrival of nanoscience and nanotechnology to medicine, hopes for early diagnosis and treatment of AD have considerably increased. To this end, nanobioresearchers are focused on three major areas consisting of early detection and recognition, biological markers and diagnosis, and pharmacotherapy. Several efforts are in progress for the discovery of new nanodrugs with a sufficient effort on the fast therapy of AD. In this review, a comprehensive overview of the conventional theories together with new conflicts and challenges on the major causes of AD is provided. In addition, the opportunities and challenges of nanoscience and nanotechnology as theranostic agents for AD are discussed in detail.

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Non-steroidal anti-inflammatory drugs may modulate the protease activity of Candida albicans

Cited by 19 publications

References 46 publications

Antimicrobial Effects of Antipyretics

Antimicrobial Effects of Antipyretics

Modulatory Effects of Dexamethasone upon Virulence Attributes of Pseudomonas Aeruginosa ATCC® 27853™

Interdisciplinary challenges and promising theranostic effects of nanoscience in Alzheimer's disease

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