Non-steroidal anti-inflammatory drugs for athletes: An update

Ziltener, Jean-Luc; Leal, Sandra Maria Cezar; Fournier, Pierre‐Edouard

doi:10.1016/j.rehab.2010.03.001

Cited by 121 publications

(91 citation statements)

References 45 publications

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“…Therefore, NSAIDs are no longer recommended for chronic soft tissue (ligament) injuries, and their use is cautioned in athletes who have ligament injuries. In the case of acute ligament injuries, NSAIDs should be used for the shortest period of time possible, if used at all [140,141].…”

Section: Nonsteroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

Ligament Injury and Healing: A Review of Current Clinical Diagnostics and Therapeutics

Hauser¹

2013

TOREHJ

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Ligament injuries are among the most common causes of musculoskeletal joint pain and disability encountered in primary practice today. Ligament injures create disruptions in the balance between joint mobility and joint stability, causing abnormal force transmission through the joint, which results in damage to other structures in and around the joint. The long-term consequence of nonhealed ligament injury is osteoarthritis, the most common joint disorder in the world today.Ligaments heal through a distinct sequence of cellular events that take place in three consecutive stages: an acute inflammatory phase, a proliferative or regenerative phase, and a tissue remodeling phase. The process can take months to resolve itself, and despite advances in therapeutics, many ligaments do not regain their normal tensile strength.Various diagnostic procedures have been used to determine and assess ligament injury. Traditionally, MRI and X-rays have been the most utilized techniques; however, because ligaments do not show up clearly with these devices, there have been many false positives and negatives reported due to inconclusive or inaccurate readings. Newer technologies, such as ultrasound and digital motion X-ray, are able to provide a more detailed image of a ligament's structure and function.Numerous strategies have been employed over the years attempting to improve ligament healing after injury or surgery. One of the most important of these is based on the understanding that monitoring early resumption of activity can stimulate repair and restoration of function and that prolonging rest may actually delay recovery and adversely affect the tissue's response to repair. Likewise, there is a shift away from the use of steroid injections and nonsteroidal antiinflammatory medications. Although these compounds have been shown effective in decreasing the inflammation and pain of ligament injuries for up to six to eight weeks, their use has been shown to inhibit the histological, biochemical, and biomechanical properties of ligament healing. For this reason their use is cautioned against in athletes who have ligament injuries. Such products are no longer recommended for chronic soft tissue injuries or for acute ligament injuries, except for the shortest possible time, if at all.Regenerative medicine techniques, such as prolotherapy, have been shown, in both case series and clinical studies, to resolve ligament injuries of the spine and peripheral joints. More research and additional studies are needed to better assess ligament injuries and healing properties.

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Section: Nonsteroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

Ligament Injury and Healing: A Review of Current Clinical Diagnostics and Therapeutics

Hauser¹

2013

TOREHJ

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“…Phase 1 of that protocol begins with pain control provided via ice massage, physical therapy modalities, and oral analgesic medications. The use of non-steroidal antiinflammatory drug (NSAIDs) should be avoided due to its potential adverse effect on bone healing [19]. Weight bearing as tolerated is allowed for daily activities, but participation in sports should be discontinued.…”

Section: Treatment For Stress Fracturesmentioning

confidence: 99%

Update on stress fractures in female athletes: epidemiology, treatment, and prevention

Chen

Tenforde

Fredericson

2013

Curr Rev Musculoskelet Med

107

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Stress fractures are a common type of overuse injury in athletes. Females have unique risk factors such as the female athlete triad that contribute to stress fracture injuries. We review the current literature on risk factors for stress fractures, including the role of sports participation and nutrition factors. Discussion of the management of stress fractures is focused on radiographic criteria and anatomic location and how these contribute to return to play guidelines. We outline the current recommendations for evaluating and treatment of female athlete triad. Technologies that may aid in recovery from a stress fracture including use of anti-gravity treadmills are discussed. Prevention strategies may include early screening of female athlete triad, promoting early participation in activities that improve bone health, nutritional strategies, gait modification, and orthotics.

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“…Yet, its use should be limited to short-term treatments (we have tested only up to 8 weeks). Ibuprofen medication may inhibit skeletal muscle hypertrophy and adaptation [42,[84][85][86], although a more recent study shows no efect of ibuprofen on muscle hypertrophy [43]. Long-term use of ibuprofen-related NSIADs could increase gastrointestinal bleeding, renal toxicity, risk of myocardial infarction, and hypertension [87,88].…”

Section: Caveats Of Ibuprofen Usementioning

confidence: 99%

Ibuprofen as a Treatment for Work-Related Musculoskeletal Disorders: Effectiveness versus Caveats

Barbe¹,

Barr-Gillespie²

2017

Occupational Health

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Work-related upper limb disorders (WMSDs), also known as repetitive strain injuries, afect a large subsection of the US population. These disorders are a signiicant source of injury, morbidity, loss of work, and pain. We have developed a rat model of upper extremity repetitive work at high forces, and observed exposure-dependent increased inlammatory responses in all tissues involved in performing the task. A 2-to 8-week regimen of oral ibuprofen provided to rats while they continued to perform a highrepetition high-force task ameliorated these inlammatory responses as well as several motor declines. Ibuprofen treatment also atenuated task-induced tissue ibrosis, cartilage degeneration, and bone osteopenia, indicating their link to inlammatory processes. However, ibuprofen did not signiicantly atenuate persistent nocifensive pain behaviors (relexive grip strength results are presented) likely because of persistent increases in inlammatory cytokines in the spinal cord, suggestive of central sensitization. Since long-term ibuprofen use can induce a number of negative side efects, such as gastritis, multi-pronged approaches should be considered with anti-inlammatory drugs included for only short time periods.

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Non-steroidal anti-inflammatory drugs for athletes: An update

Cited by 121 publications

References 45 publications

Ligament Injury and Healing: A Review of Current Clinical Diagnostics and Therapeutics

Ligament Injury and Healing: A Review of Current Clinical Diagnostics and Therapeutics

Update on stress fractures in female athletes: epidemiology, treatment, and prevention

Ibuprofen as a Treatment for Work-Related Musculoskeletal Disorders: Effectiveness versus Caveats

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