Non‐steroidal anti‐inflammatory drugs, aspirin and newly diagnosed colitis: a case–control study

Abstract

SUMMARYBackground: There have been a number of reports of colitis following exposure to non-steroidal anti-inflammatory drugs (NSAIDs) and salicylates. Aim: To conduct a case-control analysis of new cases of colitis, with particular reference to the usage of NSAIDs and salicylates prior to the development of the disease. Methods: One hundred and five consecutive new cases of colitis presenting to a single gastroenterologist were questioned about their recent usage of NSAIDs and salicylates. For comparison, the frequency of usage of these compounds was studied in two groups of 105 ageand sex-matched controls taken from hospital in-patients and community cases attending the Accident and Emergency Department.

Risk factors associated with the development of ischemic colitis

“…NSAIDs in general, and ASA in particular, are known to have a harmful effect on the gastrointestinal tract. NSAIDsrelated colitis has been described in connection with both short- [12,22] and long-term treatments [23] . Different clinical observations and case-control studies have linked the use of NSAIDs or salicylates to diagnosis of acute diarrhea syndrome [24] and exacerbation of inflammatory colitis (ulcerative colitis or Crohn's disease) [23] .…”

The protective effect of eupatilin on indomethacin-induced cell damage in cultured feline ileal smooth muscle cells: Involvement of HO-1 and ERK

“…cause inflammatory lesions in the small intestine in about 60% of patients using them long term (Smale et al, 2001), and as many as 75% of patients with erosive colitis are chronic NSAIDs users (Gleeson and Davis, 2003). NSAIDs induce peptic ulceration and injury to the small and large intestine causing increased permeability with protein and blood loss and stricture formation (Hawkey, 1993;Rainsford, 1993).…”

Ischemic Colitis: Characteristics and Predictive Factors of Severity, in Hospital Mortality and Relapse

“…ciated colitis has been associated to both short term [21,23] and long term treatments [22]. In our series we can not determine if there is any relation between the onset of I.C.…”

“…NSAIDs and salycilates have been largely associated to several forms of colitis, including I.C [21][22][23]. Studies in the TNBS model confirmed the ability of NSAIDs to exacerbate colitis [24].…”