Non-steroidal anti-inflammatory drugs and risk of Parkinson’s disease in the elderly population: a meta-analysis

Poly, Tahmina Nasrin; Islam, Mohaimenul; Yang, Hsuan-Chia; Li, Yu-Chuan

doi:10.1007/s00228-018-2561-y

Cited by 82 publications

(61 citation statements)

References 42 publications

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“…Fruits and vegetables intake were included as a marker for healthy eating, and vitamin and supplement intake were included as a marker for health seeking behavior. Aspirin use was included as a confounder for its potential anti-inflammatory properties although its relation with PD is not clear-cut [ 22 , 23 ]. Missing information on covariates were imputed by multiple imputation using chaired equations (twenty imputations).…”

Section: Methodsmentioning

confidence: 99%

Milk and Fermented Milk Intake and Parkinson’s Disease: Cohort Study

et al. 2020

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Milk and fermented milk consumption has been linked to health and mortality but the association with Parkinson’s disease (PD) is uncertain. We conducted a study to investigate whether milk and fermented milk intakes are associated with incident PD. This cohort study included 81,915 Swedish adults (with a mean age of 62 years) who completed a questionnaire, including questions about milk and fermented milk (soured milk and yogurt) intake, in 1997. PD cases were identified through linkage with the Swedish National Patient and Cause of Death Registers. Multivariable-adjusted hazard ratios were obtained from Cox proportional hazards regression models. During a mean follow-up of 14.9 years, 1251 PD cases were identified in the cohort. Compared with no or low milk consumption (<40 mL/day), the hazard ratios of PD across quintiles of milk intake were 1.29 (95% CI 1.07, 1.56) for 40–159 mL/day, 1.19 (95% CI 0.99, 1.42) for 160–200 mL/day, 1.29 (95% CI 1.08, 1.53) for 201–400 mL/day, and 1.14 (95% CI 0.93, 1.40) for >400 mL/day. Fermented milk intake was not associated with PD. We found a weak association between milk intake and increased risk of PD but no dose–response relationship. Fermented milk intake was not associated with increased risk of PD.

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Section: Methodsmentioning

confidence: 99%

Milk and Fermented Milk Intake and Parkinson’s Disease: Cohort Study

et al. 2020

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“…This cautionary conclusion has not been validated in further studies, such as the one by Ren et al (2018) who, upon considering 15 studies, concluded that the consumption of non-steroidal anti-inflammatory drugs is not associated with PD risk (Ren et al, 2018). The most recent work including 17 studies with 14,713 patients within circa 2,5 million participants also failed to find an association between non-steroidal anti-inflammatory drugs and PD risk at the population level (Poly et al, 2019). Authors riveted: ''clinicians need to be vigilant ensuring that the use of NSAIDs remains restricted to their approved anti-inflammatory and analgesic effect.…”

Section: Inflammation and Infection As Risk Factors Of Parkinson's DImentioning

confidence: 95%

Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson’s Disease

Franco

Rivas‐Santisteban

Reyes‐Resina

et al. 2020

Front. Aging Neurosci.

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The exact cause of Parkinson's disease (PD), the second most prevalent neurodegenerative disease in modern societies, is still unknown. Many scientists point out that PD is caused by a complex interaction between different factors. Although the main risk factor is age, there are other influences, genetic and environmental, that individually or in combination may trigger neurodegenerative changes leading to PD. Nowadays, research remains focused on better understanding which environmental factors are related to the risk of developing PD and why. In line with the knowledge on evidence on exposures that prevent/delay PD onset or that impact on disease progression, the aims of this review were: (i) to comment on the non-genetic risk factors that mainly affect idiopathic PD; and (ii) to comment on seemingly reliable preventive interventions. We discuss both environmental factors that may affect the central nervous system (CNS) or the intestinal tract, and the likely mechanisms underlying noxious or protective actions. Knowledge on risk, protective factors, and mechanisms may help to envisage why nigral dopaminergic neurons are so vulnerable in PD and, eventually, to design new strategies for PD prevention and/or anti-PD therapy. This article reviews the variety of the known and suspected environmental factors, such as lifestyle, gut microbiota or pesticide exposition, and distinguishes between those that are harmful or beneficial for the PD acquisition or progression. In fact, the review covers one of the most novel players in the whole picture, and we address the role of microbiota on keeping a healthy CNS and/or on preventing the "side-effects" related to aging.

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Section: Generic View Of Pd Pathogenesismentioning

confidence: 99%

“…Several meta-analyses revealed the association between the use of NSAIDs and the risk of PD (Samii et al, 2009; Gagne and Power, 2010; Gao et al, 2011; Rees et al, 2011; Poly et al, 2019), whereas the relationship was inconclusive. NSAIDs as a whole seemed not to be related to the risk of PD (Samii et al, 2009; Poly et al, 2019). Interestingly, subgroup analysis indicated that use of nonaspirin NSAIDs may have a protective effect, though not shared by aspirin (Gagne and Power, 2010; Rees et al, 2011) or acetaminophen (Gagne and Power, 2010; Gao et al, 2011).…”

Section: Generic View Of Pd Pathogenesismentioning

confidence: 99%

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

Liu

Wang

Liu

et al. 2019

Front. Cell. Neurosci.

102

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Mounting evidence suggests that neuroinflammation is not just a consequence but a vital contributor to the development and progression of Parkinson’s disease (PD). Microglia in particular, may contribute to the induction and modulation of inflammation in PD. Upon stimulation, microglia convert into activated phenotypes, which exist along a dynamic continuum and bear different immune properties depending on the disease stage and severity. Activated microglia release various factors involved in neuroinflammation, such as cytokines, chemokines, growth factors, reactive oxygen species (ROS), reactive nitrogen species (RNS), and prostaglandins (PGs). Further, activated microglia interact with other cell types (e.g., neurons, astrocytes and mast cells) and are closely associated with α-synuclein (α-syn) pathophysiology and iron homeostasis disturbance. Taken together, microglial activation and microglia-mediated inflammatory responses play essential roles in the pathogenesis of PD and elucidation of the complexity and imbalance of microglial activation may shed light on novel therapeutic approaches for PD.

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Non-steroidal anti-inflammatory drugs and risk of Parkinson’s disease in the elderly population: a meta-analysis

Cited by 82 publications

References 42 publications

Milk and Fermented Milk Intake and Parkinson’s Disease: Cohort Study

Milk and Fermented Milk Intake and Parkinson’s Disease: Cohort Study

Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson’s Disease

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

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