Non-steroidal anti-inflammatory drug (NSAID)-induced colonic strictures and perforation: A case report

Aloysius, Mark M.; Kaye, P.V.; Lobo, Dileep N.

doi:10.1016/j.dld.2005.09.003

Cited by 48 publications

(14 citation statements)

References 15 publications

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“…Although the first cases of diaphragm‐like lesions (lesions pathognomonic of NSAIDs) were described in the small intestine, similar lesions have also been noted in the colon, especially in patients taking sustained‐release preparations …”

Section: Ulcerative Pattern Of Injurymentioning

confidence: 87%

Iatrogenic pathology of the intestines

2015

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Many drugs and chemical agents can cause enteritis and colitis, producing clinical gastrointestinal side effects, the most common of which are diarrhoea, constipation, nausea and vomiting. Significant histological overlap exists between some patterns of medication or chemical injury and various disease entities. A particular medication may cause multiple patterns of injury and may mimic common entities such as coeliac disease, Crohn's disease, infectious enteritis and colitis. Thus, given the common absence of specific histopathological features, the diagnosis often relies upon thorough clinicopathological correlation. This review concentrates on selected examples of medication-induced injury of the intestinal tract in which the pathology can be recognized, particularly on biopsies, with a focus on newly described medication-induced gastrointestinal effects.

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Section: Ulcerative Pattern Of Injurymentioning

confidence: 87%

Iatrogenic pathology of the intestines

2015

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“…However, in two of the three previously reported patients with colonic perforation due to NSAIDs the perforation occurred in the transverse colon, and in the other patient the perforation occurred in the caecum [15][16][17]. In the small number of reports on the effects of NSAIDs in the colon no specific site has been mentioned.…”

Section: Discussionmentioning

confidence: 85%

Colonic perforation after short-term use of nonsteroidal antiinflammatory drugs: report of two cases

et al. 2008

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Nonsteroidal antiinflammatory drugs are widely used for acute and chronic pain, but they may have serious side effects such as impairment of renal function, asthma, erosions of the mucosa in the gastrointestinal tract, colonic and intestinal strictures, and gastrointestinal tract bleeding. Although the upper gastrointestinal tract disturbances caused by nonsteroidal antiinflammatory drugs are well known, their side effects in the lower gastrointestinal tract are not clearly defined. There are a limited number of articles and case reports about the latter in the literature. We report two cases of colonic perforation due to short-term use of nonsteroidal antiinflammatory drugs in this study. Colonic perforation should be considered as one of the possible diagnoses in patients with acute abdominal pain and nonsteroidal antiinflammatory drug use should be considered as a possible cause of colonic perforation if other possibilities are excluded.

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“…Her only other medication was spasmonal, again on an as required basis. The endoscopic appearances are well described in non-steroidal anti-inflammatory drug (NSAID)-related colopathy 1 – 3. Histology confirmed the presence of granulation tissue in the lamina propria and very mild neutrophilic cryptitis, in keeping with active inflammation.…”

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confidence: 76%

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Non-steroidal anti-inflammatory drug (NSAID)-induced colonic strictures and perforation: A case report

Cited by 48 publications

References 15 publications

Iatrogenic pathology of the intestines

Iatrogenic pathology of the intestines

Colonic perforation after short-term use of nonsteroidal antiinflammatory drugs: report of two cases

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