Non-steroid Inhibitors of Pituitary Gonadotrophic Function

Effect of Some Chemicals on Spermatogenesis in Rhesus Monkeys

“…Methallibure has been reported to suppress the oestrous cycle in rats and menstruation in rhesus monkeys through an inhibition of pituitary gonadotrophic activity (Paget, Walpole & Richardson, 1961). A reduction in urinary excretion of pituitary gonadotrophin has been observed in post-menopausal cases, in women of reproductive age and in men with prostatic carcinoma (Walpole, 1965).…”

Effects of 1- -Methylallylthiocarbamoyl-2-Methylthiocarbamoylhydrazine (I.C.I. 33,828) on Early Pregnancy in the Rat

“…Mears suggested that this discrepancy might have been due to the difference in the ages of the patients treated in the two experiments. Paget et al (1961) observed that when I.C.I. 33,828 was given orally to rats at a dose of 100 mg/kg on any 3 consecutive days of pregnancy, no litters were obtained.…”

The Influence of the Route of Administration of 1-Alpha-Methylallylthiocarbamoyl-2-Methylthiocarbamoylhydrazine on Reproduction in Rats and Mice

“…However, they were unable to determine whether it specifically blocked fsh or lh. (Paget et al, 1961). Bell, Brown, Fotherby & Loraine (1962) and Mears (1962) presented contradictory information on the effect of Compound I.C.I.…”

“…33,828) has a marked effect on fertility in some species, but not in others. Paget, Walpole & Richardson (1961), working with several species, concluded provisionally that it had either a direct effect on the production of gonadotrophins by the pituitary, or an effect on the presumed hypothalamic control ofthat function. Brown (1963) concluded that it specifically inhibited formation of the gonadotrophins by the anterior pituitary gland.…”