Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation
Mathijs P. Verhagen,
Rosalie Joosten,
Mark Schmitt
et al.
Abstract:According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, has been shown to suppress intestinal stemness. Here, we used Paneth cells as a model to assess the capacity of differentiated lineages to trigger tumorigenesis in the context of inflammation in mice. Upon inflammation, Paneth cell-specific Apc mutations led to intestinal tumors reminiscent not only of those arising in patients with inflammatory bowel disease, but also of a large… Show more
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