Non-spherical particles for targeted drug delivery

Chen, Jinrong; Clay, Nicholas E.; Park, No Hyung; Kong, Hyun Joon

doi:10.1016/j.ces.2014.10.022

Cited by 79 publications

(55 citation statements)

References 30 publications

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“…Several methodologies have been proposed to produce particles with complex shapes. [89][90][91][92][93] One versatile technique proposed by Mitragotri's group permitted to obtain a wide range of particles shapes comprising sizes between 60 nm and 30 µm, based on the stretching of spherical particles. [ 91 ] Polyvinyl alcohol fi lms prepared from a suspension containing spherical polymeric particles were stretched enabling the production of particles with different shapes.…”

Section: Reviewmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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Section: Reviewmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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“…For example, one can have a colloidal solution of Janus particles that are concentrated enough to come close to each other, so that their (steric, electrostatic, hydrodynamic) interaction should be considered for a correct description of their collective behaviour [31][32][33] or a colloidal particle in a bacterial bath in the presence of an external optical potential inducing on the particles a driving force in the direction of the light intensity gradient [30]. Another common case are active dynamics of non-spherical particles like elongated rods [34][35][36][37] or chiral particles [38][39][40] in 3D or the presence of a boundary [41,42] that alters the value of the diffusion constant in its proximity via a diffusion gradient [43].…”

Section: More Complex Modelsmentioning

confidence: 99%

Numerical Simulations of Active Brownian Particles

Callegari

Volpe

2019

Soft and Biological Matter

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“…It should be emphasized that we are talking only about real pharmaceuticals that have official permission for medical use. The biological properties of different crystal forms of new substances, which have the prospect of becoming a drug but so far have not, have recently been studied and described rather widely [41][42][43][44][45][46][47]. As a rule, polymorphic modifications of a substance are tested, i.e., samples that differ significantly not only in habitus, but also in the molecular and crystal structure.…”

Section: Evaluation Of the Biological Propertiesmentioning

confidence: 99%

Crystal Habits and Biological Properties of N-(4-Trifluoromethylphenyl)-4-Hydroxy-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxamide

et al. 2019

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In order to study polymorphic modifications of N-(4-trifluoromethylphenyl)-4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide, which is of interest as a promising analgesic, its three colorless crystal forms with different habitus have been obtained: sticks of ethyl acetate, plates of meta-xylene and blocks of ortho-xylene. However, the X-ray diffraction analysis has shown that all the forms studied have the identical molecular and crystal structure in spite of such significant differences in appearance. Moreover, pharmacological tests have revealed significant differences in the analgesic activity in these samples (a total of five experimental models were used: “acetic-acid-induced writhing”, “hot plate”, “thermal irritation of the tail tip” (tail-flick), “tail electric stimulation” and “neuropathic pain”), acute toxicity and the ability to cause gastric damage. As a result, only the plate crystal form of N-(4-trifluoromethylphenyl)-4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide is recommended for further studies. Thus, it has been proven that the habitus of crystals is an important characteristic of the drug substance and is able to have a noticeable effect on its biological properties. Changes in habitus should be considered as a guide to the mandatory verification of at least the basic pharmacological parameters of the new form regardless of whether the molecular and crystal structure changes.

show abstract

Non-spherical particles for targeted drug delivery

Cited by 79 publications

References 30 publications

Design Advances in Particulate Systems for Biomedical Applications

Design Advances in Particulate Systems for Biomedical Applications

Numerical Simulations of Active Brownian Particles

Crystal Habits and Biological Properties of N-(4-Trifluoromethylphenyl)-4-Hydroxy-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxamide

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