Non-Specific Parameters of Immune Response as a Ring in the Pathogenesis of Remodeling of the Vascular Wall and Destruction of Bone Tissue in Women With Arterial Hypertension in Postmenapus

Abstract

Recently, they increasingly began to pay attention to the role of a nonspecific immune-inflammatory vascular response as a link in general pathogenetic mechanisms with a change in the elastic properties of arteries and phenomena of destructive bone changes, which at the subclinical level is of great importance for the prevention of the development of socially significant diseases. A total of 104 patients were examined (mean age 57.45 years), which were divided into three groups. The first group included 39 healthy women, the second group included 30 patients with hypertension and osteopenia, and the third group included 35 women with hypertension and osteoporosis. The analysis of markers of the immune inflammatory response, endothelial dysfunction, hormonal and mineral-vitamin status parameters was conducted against the background of the study of parameters of daily monitoring of arterial pressure, study of parameters of vascular wall stiffness and densitometry to clarify the predictors of cardiovascular and degenerative bone changes in postmenopausal women. A significant increase in the concentration of HF-CRP, the level of homocystemine, IL-8, parathyroid hormone, against the background of a significant decrease in the level of estrogen, progesterone, testosterone, with a persistent tendency to increase in total cholesterol, atherogenic lipid fractions, myeloperoxidase, endothelin-1 and decrease was recorded calcitonin, total and ionized calcium, with a significantly minimal value of vitamin D in the 3rd group of patients. The risks of development and progression of bone destructive changes were calculated using the logistic regression method for the group of AH with osteopenia and osteoporosis. Thus, for patients with hypertension and osteopenia, a significantly significant parameter associated with the risk of developing osteoporosis was an indicator of the velocity of the pulse wave, an increase in the level of which exceeds 12.05 m/s is associated with an increased risk of developing osteoporosis by 3.8 times. Increased levels of pro-inflammatory parameters, IL-6 and 8, TNF-α, HB-SRB, parathyroid hormone and reduced levels of progesterone and IL10, took the most active part in aggravating the degree of available bone tissue destruction. Timely specialized multidirectional study of biochemical and instrumental parameters (in particular, the study of the speed of the pulse wave and densitometry) can be the basis for the development of personalized prevention and treatment tactics for women in order to prevent socially dangerous cardiovascular and bone complications

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“…Our study demonstrated gender-and age-related changes in the metabolome of the intestinal microbiota in patients with AH and abdominal obesity. In our earlier study, we observed a significant increase in the levels of TMA and TMAO, IL-1.6, hs-CRP and GDF15 and a decrease in the levels of SCFA, adiponectin, sex hormones, intestinal hormones and calcium in the presence of multidirectional correlations of biomarkers with PWV and left ventricular hypertrophy [16].…”

Deteriorated Vascular Homeostasis in Hypertension: Experimental Evidence from Aorta, Brain, and Pancreatic Vasculature

“…These alterations are essential in order to reinforce the arterial tissue against excessive strain and probable dissection [ 7 , 8 ]. Similar examples of remodeling in connective tissues, e.g., bones [ 9 ], are well-documented. This remodeling pathway continues to depose ECM until the source cell is no longer experiencing loads and strains well above the physiological levels.…”

Neobavaisoflavone protects osteoblasts from dexamethasone‐induced oxidative stress by upregulating the CRNDE‐mediated Nrf2/HO‐1 signaling pathway

“…A recent survey suggests that osteoporosis affects millions of people in the United States, and that most patients are postmenopausal women with low estrogen levels (Patel, 2020). Although the specific pathogenesis of osteoporosis is not fully understood, previous studies have shown that the main causes of osteoporosis are estrogen deficiency and immune inflammatory response (Park et al, 2020; Petelina et al, 2019). In recent years, great progress has been made in studying the relationship between oxidative stress and disease, in which studies have shown that oxidative stress can inhibit the differentiation of osteoblasts and promote the development of osteoporosis (Takanche et al, 2020).…”