Non-specific impairment of Lung Function on Spirometery in Patients with Chronic Hepatitis-C

Zuberi, Faisal Faiyaz; Zuberi, Bader Faiyaz; Rasheed, Tazeen; Nawaz, Zunaira

doi:10.12669/pjms.35.2.73

Cited by 4 publications

(5 citation statements)

References 25 publications

(34 reference statements)

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“…Notably, in some studies, these dysfunctions were shown to be associated with the severity of liver cirrhosis, as assessed by various scores, such as the Child Pugh Score and the Model for End-Stage Liver Disease (MELD) score, clinical characteristics such as ascites and laboratory parameters such as albumin ( 11 , 13 , 19 , 20 , 23 , 26-28 , 32 , 33 , 35 , 36 , 40 ). Some studies ( 19 , 20 , 23 , 33 , 35 ) have found a significant association between decreasing PEFR, FVC, FEV1 and FEF25-75% values, and increasing ascites.…”

Section: Spirometrymentioning

confidence: 99%

“…Of note, in a study evaluating the presence of non-specific impairment of lung functions (NILF), defined as the observation of any two of three following criteria: i) FVC <80% of predicted; ii) FEV1 <80% of predicted; iii) FEV1/FVC ≥70, NILF was statistically associated with the female sex and with increasing FibroScan scores ( 40 ).…”

Section: Spirometrymentioning

confidence: 99%

“…Variations in the values of FEV1, FVC, PEFR and FEF25-75% have been described in patients with liver cirrhosis (13,15,. More specifically, some researchers (13,15,18,27,32) have reported obstructive dysfunction, while others (19,21,23,25,26,31,33,38) reported obstructive and/or restrictive ventilatory abnormalities, and some researchers (11,20,(22)(23)(24)(28)(29)(30)32,(34)(35)(36)(37)39,40) found isolated declines in the absolute values of FEV1, FVC, PEFR and/or FEF25-75%.…”

Section: Spirometrymentioning

confidence: 99%

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Pulmonary function testing in patients with liver cirrhosis (Review)

Georgakopoulou

Asimakopoulou

2023

Med Int

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Liver cirrhosis is a common long-term outcome of chronic hepatic inflammation. Patients with liver cirrhosis may also have pulmonary complications. There are several reasons for pulmonary dysfunction in liver cirrhosis, including intrinsic cardiopulmonary dysfunction unrelated to liver disease and specific disorders related to the presence of liver cirrhosis and/or portal hypertension. The most prevalent and clinically significant pulmonary complications are hepatic hydrothorax, hepatopulmonary syndrome, spontaneous pulmonary empyema and portopulmonary hypertension. Pulmonary function tests (PFTs) have traditionally been used to assess the lung function of patients with liver cirrhosis. To the best of our knowledge, the present review is the first to detail all types of PFTs performed in patients with liver cirrhosis and discuss their clinical significance. Patients with liver cirrhosis have reduced values of spirometric parameters, diffusion capacity for carbon monoxide (DLCO), lung volumes, maximal inspiratory pressure and maximal expiratory pressure. Furthermore, they have a higher closing volume, a greater airway occlusion pressure 0.1 sec after the onset of inspiratory flow and greater exhaled nitric oxide values. In order to improve pulmonary function, patients with ascites may require therapeutic paracentesis. Such findings should be considered when evaluating individuals with liver disease, particularly those who may require surgery. Poor lung function, particularly restrictive lung disease, can have an impact on post-transplant outcomes, such as ventilator time, length of hospital duration and post-operative pulmonary complications; thus, the transplant care team needs to be aware of its prevalence and relevance.

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Section: Spirometrymentioning

confidence: 99%

Section: Spirometrymentioning

confidence: 99%

Section: Spirometrymentioning

confidence: 99%

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Pulmonary function testing in patients with liver cirrhosis (Review)

Georgakopoulou

Asimakopoulou

2023

Med Int

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“…A similar association (relative risk of 1.8) was found using the DTB. Several studies evaluated the impact of HCV infections on the development of COPD, with divergent conclusions as whether HCV is directly involved in the pathogenesis of COPD [34][35][36][37][38][39]. While most studies discussed HCV as a risk factor for the development or exacerbation of COPD, Fischer and colleagues report that HCV is not an independent risk factor for obstructive lung disease [37].…”

Section: Plos Onementioning

confidence: 99%

Gender-specific disease trajectories prior to the onset of COPD allow individualized screening and early intervention

et al. 2023

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Background Nation-wide hospitalization databases include diagnostic information at the level of an entire population over an extended period of time. Comorbidity network and early disease development can be unveiled. Chronic obstructive pulmonary disease (COPD) is an underdiagnosed condition for which it is crucial to identify early disease indicators. The identification of gender-specific conditions preceding the onset of COPD may reveal disease progression patterns allowing for early diagnosis and intervention. The objective of the study was to investigate the antecedent hospitalization history of patients newly diagnosed with COPD and to retrace a gender-specific trajectory of coded entities prior to the onset of COPD. Material and methods A population-wide hospitalization database including information about all hospitalizations in Switzerland between 2002 and 2018 was used. COPD cases were extracted from the database and comorbidities occurring prior to the onset of COPD identified. Comorbidities significantly over-represented in COPD compared with a 1:1, age- and sex-matched control population were identified and their longitudinal evolution was analyzed. Results Between 2002 and 2018, 697,714 hospitalizations with coded COPD were recorded in Switzerland. Sixty-two diagnoses were significantly over-represented before onset of COPD. These preceding comorbidities included both well-established conditions and novel links to COPD. Early pre-conditions included nicotine and alcohol abuse, obesity and cardiovascular diseases. Later comorbidities included atrial fibrillation, diseases of the genitourinary system and pneumonia. Atherosclerotic heart diseases were more prevalent in males, whereas hypothyroidism, varicose and intestinal disorders were more frequent in females. Disease trajectories were validated using an independent data set. Conclusions Gender-specific disease trajectories highlight early indicators and pathogenetic links between COPD and antecedent diseases and could allow for early detection and intervention.

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“…In southern Taiwan, hepatitis C virus ( HCV) is endemic, and it has been shown to lead to dysmetabolic syndrome 12 with hypocholesteremia, hepatic steatosis, and large abdominal girth, which are risk factors for iPF. 13, 14 Chronic HCV infection has also been associated with a worse prognosis in asthmatic patients 15 and chronic obstructive pulmonary disease. 16 The additional influence of HCV on lung function decline 17 has been associated with pulmonary fibrosis 18 and reduced lung capacity through immune-mediated reactions.…”

Section: Introductionmentioning

confidence: 99%

Association between viral hepatitis and metabolic syndrome in lung function impairment: A Taiwan community-based study

et al. 2022

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Objectives Metabolic syndrome (MetS) and hepatitis C virus (HCV) are associated with a higher risk of impaired pulmonary function (iPF). This study aimed to investigate the relationships among MetS, iPF, and viral hepatitis. Methods This community-based study enrolled participants undergoing annual health check-ups in southern Taiwan between March and December 2019. We performed multivariable logistic regression analyses adjusted for demographics and characteristics to identify the factors associated with iPF. Results A total of 2337 participants completed examinations, of whom 928 (39.7%) had iPF. The participants with iPF were elderly (68.8 ± 12.8 years old) and predominately female (63%). MetS increased the risk of iPF (odds ratio (OR) 1.51, 95% confidence interval (CI) 1.27–1.81, p < 0.001). Beyond age (OR 1.03, 95% CI 1.02–1.04) and smoking (OR 1.309, 95% CI 1.004–1.705), female sex (OR 0.74, 95% CI 0.59–0.93) and high education level (OR 0.96, 95% CI 0.94–0.98, p < 0.001) protected against iPF. HCV was not significantly associated with iPF (OR 1.17, 95% CI 0.90–1.52, p = 0.235) in multivariable analysis. MetS was associated with a higher risk of iPF in the non-HBV/HCV group (OR 1.86, 95% CI 1.54–2.26) and HBV alone group (OR 3.44, 95% CI 1.89–6.28), but not in the HCV alone group (OR 1.02, 95% CI 0.64–1.62). Discussion MetS was an independent predictor of iPF, especially the restrictive type, and had different effects in the HBV/non-viral hepatitis and HCV groups. Female sex and education were inversely associated with iPF.

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Non-specific impairment of Lung Function on Spirometery in Patients with Chronic Hepatitis-C

Cited by 4 publications

References 25 publications

Pulmonary function testing in patients with liver cirrhosis (Review)

Pulmonary function testing in patients with liver cirrhosis (Review)

Gender-specific disease trajectories prior to the onset of COPD allow individualized screening and early intervention

Association between viral hepatitis and metabolic syndrome in lung function impairment: A Taiwan community-based study

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