Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model
Rosa Casais,
Natalia Iglesias,
Iker A. Sevilla
et al.
Abstract:Tuberculosis BCG vaccination induced non-specific protective effects in humans led to postulate the concept of trained immunity (TRAIM) as an innate type of immune mechanism that triggered by a pathogen, protects against others. Killed vaccines have been considered not to be effective. However, field efficacy of a commercial vaccine against paratuberculosis, as well as of a recently developed M. bovis heat-inactivated vaccine (HIMB) prompted to test whether it could also induce TRAIM. To this, we used a sarcop… Show more
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