Non-specific benign pathological results on transthoracic core-needle biopsy: how to differentiate false-negatives?

Kim, Jung Im; Park, Chang Min; Kim, Hyungjin; Lee, Jong Hyuk; Goo, Jin Mo

doi:10.1007/s00330-017-4766-3

Cited by 40 publications

(61 citation statements)

References 30 publications

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“…Malignancies appear to be more frequent in sub‐solid nodules than in solid nodules . Most sub‐solid lung nodules tend to correspond to early‐stage lung cancer or precancerous lesions .…”

Section: Discussionmentioning

confidence: 99%

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Computed tomography‐guided coil localization for video‐assisted thoracoscopic surgery of sub‐solid lung nodules: a retrospective study

Teng

Wang

et al. 2019

ANZ Journal of Surgery

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Background Wedge resection via video‐assisted thoracoscopic surgery (VATS) is the best choice for the diagnosis of sub‐solid lung nodules. Preoperative localization is utilized to increase the success rate of this procedure. We aimed to evaluate the effectiveness of preoperative coil localization in VATS wedge resection for sub‐solid lung nodules. Methods From October 2015 to August 2018, 42 patients with 55 sub‐solid lung nodules underwent computed tomography‐guided coil localization with subsequent VATS wedge resection in our centre. Data regarding visible coil rates, technical success of the wedge resection and pathological results were collected and analysed retrospectively. Results A total of 55 sub‐solid lung nodules were localized in 42 patients. Thirty‐three patients had one nodule and nine patients had multiple nodules. Fifty‐two coils (52/55, 94.5%) were visible during the VATS. The mean duration of each coil localization was 14.3 ± 4.8 min (range 7–40 min). Three patients (7%) experienced pneumothorax after coil localization. VATS wedge resection was successfully performed for 53 nodules (53/55, 96.4%). The remaining two nodules were treated directly with lobectomy. The nine patients who had multiple nodules underwent one‐stage VATS wedge resection of all nodules. The mean duration of the VATS in the 42 patients was 159.3 ± 83.4 min (range 60–360 min) while the mean blood loss was 119.3 ± 115.3 mL (range 10–700 mL). Conclusion Preoperative computed tomography‐guided coil localization is a safe and effective method to facilitate high success rates for diagnostic VATS wedge resection for sub‐solid nodules.

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Section: Discussionmentioning

confidence: 99%

“…Malignancies appear to be more frequent in sub-solid nodules than in solid nodules. 10,11 Most sub-solid lung nodules tend to correspond to early-stage lung cancer or precancerous lesions. [7][8][9] Surgical resection may provide nearly 100% disease-free survival for patients with sub-solid lung nodules.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography‐guided coil localization for video‐assisted thoracoscopic surgery of sub‐solid lung nodules: a retrospective study

Teng

Wang

et al. 2019

ANZ Journal of Surgery

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“…LN is defined as a round or oval lesion ≤ 3 cm that is completely surrounded by pulmonary parenchyma without other abnormalities [1][2][3][4]. CNB-based benign results can be divided into specific and non-specific benign results [10]. Specific benign results were defined as benign tumors or infectious diseases with identified pathogens.…”

Section: Definitionsmentioning

confidence: 99%

“…CNB-based benign results were considered to be true-negatives if the lesions were benign upon final 6 diagnosis. A final benign diagnosis could be made in 1 of the 3 ways: (a) surgery; (b) determination of a specific benign lesion upon pathological analysis of the lung biopsy sample; or (c) a decrease > 20% in lesion diameter, stability in size (without anticancer treatment) over a minimum of 2 years [10]. If lesions did not meet the criteria mentioned above, final diagnoses were listed as non-diagnostic lesions.…”

Section: Definitionsmentioning

confidence: 99%

“…The false-negative rate of CT-guided lung biopsy was reported to be up to 16% [9]. At present, some studies have established some predictors of true-or false-negative findings from CNB-based nonspecific benign results [9,10]. However, no study has investigated true-negative findings in lung nodules (LNs) with CNB-based non-specific benign results.…”

Section: Introductionmentioning

confidence: 99%

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Computed tomography-guided cutting needle biopsy for lung nodules: when the biopsy-based benign results are real benign

Hui¹,

Yin²,

Zhou³

et al. 2019

Preprint

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Background: Computed tomography (CT)-guided cutting needle biopsy (CNB) has been widely used for the diagnosis of lung nodules (LNs). The false-negative rate of CT-guided lung biopsy is reported to be up to 16%. The aim of this study was to determine the predictors of true-negative results in LNs with CNB-based benign results. Methods: From January 2011 to December 2015, 96 patients with CNB-based non-specific benign results were included in this study as the training group to detect predictors of true-negative results. From January 2016 to December 2018, an additional 57 patients were included as a validation group to test the reliability of the predictors. Results: In the training group, a total of 96 patients underwent CT-guided CNB for 96 LNs. The CNB-based results were true-negatives for 82 LNs and false-negatives for 14 LNs. The negative predictive value of the CNB-based benign results was 85.4% (82/96). Univariate and multivariate logistic regression analyses revealed that CNB-based chronic inflammation with fibroplasias (P = 0.013, hazard ratio = 0.110, 95% confidential interval = 0.019–0.625) was the independent predictor of true-negative results. The area under the receiver operator characteristic (ROC) curve was 0.697 (P = 0.019). In the validation group, biopsy results for 47 patients were true-negative and 10 were false-negative. When the predictor was used on the validation group, the area under the ROC curve was 0.759 (P = 0.011). Conclusions: Most of the CNB-based benign results were true-negatives, and CNB-based chronic inflammation with fibroplasias could be considered a predictor of true-negative results.

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Utility of liquid‐based cytology on residual needle rinses collected from core needle biopsy for lung nodule diagnosis

Lan

Zhang

et al. 2021

Cancer Medicine

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Non-specific benign pathological results on transthoracic core-needle biopsy: how to differentiate false-negatives?

Cited by 40 publications

References 30 publications

Computed tomography‐guided coil localization for video‐assisted thoracoscopic surgery of sub‐solid lung nodules: a retrospective study

Computed tomography‐guided coil localization for video‐assisted thoracoscopic surgery of sub‐solid lung nodules: a retrospective study

Computed tomography-guided cutting needle biopsy for lung nodules: when the biopsy-based benign results are real benign

Utility of liquid‐based cytology on residual needle rinses collected from core needle biopsy for lung nodule diagnosis

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