Non-smoking non-drinking elderly females: a clinically distinct subgroup of oral squamous cell carcinoma patients

Koo, Kendrick; Barrowman, Roland A; McCullough, Michael; Iseli, Tim A.; Wiesenfeld, D.

doi:10.1016/j.ijom.2013.04.010

Cited by 58 publications

(79 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding is in agreement with the previous literature on the subject (Sherin et al, 2008;Koo et al, 2013). Conversely, studies in some other Asian countries such as Taiwan, India and Thailand have found that buccal mucosa was a common location which has strongly associated with betel quid chewing habit regionally (Iamaroon et al, 2004;Khovidhunkit et al, 2008;Kaminagakura et al, 2012;Chang et al, 2013;Krishna et al, 2014) Historically, young patients with oral cancers were believed to be particularly aggressive and carry a poor prognosis (Dahlstrom et al, 2008).…”

Section: Discussionsupporting

confidence: 88%

“…Oral squamous cell carcinoma (OSCC) is typically diagnosed in males in their fifth to seventh decade of life with long-term exposure to tobacco and alcohol (Iamaroon et al, 2004;Farshadpour et al, 2007;Hafkamp et al, 2008;Klozar et al, 2013;Koo et al, 2013). The incidence of OSCC in patients younger than 45 years has been reported to ranging from 0.4%-6.7% of all cases (Llewellyn et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan

Zheng²,

Mao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at a younger age worldwide. Clinical records of 100 patients under the age of 45 years treated specifically for oral cavity SCC in our hospital during a 10-year period were retrospectively analyzed to calculate the survival rates. An obvious male predominance coincided with smoking trend among Chinese young individuals and female patients were more likely to have no traditional risk factors such as smoking or drinking. The 5-year overall survival rate and disease-free survival rate were 61.0% and 75.5%, respectively, consistent with other published series over the decade showing a relatively better survival among the young. No significant differences clearly correlated with outcome when comparing non-smokers non-drinkers to ever-smokers and ever drinkers (P>0.05). Overall survival rate and disease free survival rate was found to be significantly higher in patients with early-stage disease than with advanced stage disease (P=0.001, P=0.009 respectively). The strong influence of clinical stage on prognosis emphasizes the importance of early diagnosis and treatment of oral malignancies for this unique clinical subgroup.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan

Zheng²,

Mao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…11 Previously published data from our institution revealed that the rate of second primary tumour in non-smoking, non-drinking patients was similar to that in patients who were smokers and/or drinkers, with all second primaries presenting in the oral cavity or oropharynx; no synchronous primaries were noted in the non-smoking, non-drinking group. 12 Given the conflicting evidence, this study aimed to review the incidence and prevalence of second primary tumours, specifically in early stage oral tongue carcinomas. The study compared nonsmoking, non-drinking patients to those with known risk factors, in order to evaluate the need for separate panendoscopy in this subgroup.…”

Section: Introductionmentioning

confidence: 99%

A role for panendoscopy? Second primary tumour in early stage squamous cell carcinoma of the oral tongue

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The occurrence and development of OSCC is a complex process which involves multi-steps, multi-factors, polygenic-alteration, and multi-stages pathopoiesis [6]. As squamous cell carcinoma originates from epithelial cells, many domestic and overseas scholars have long focused on the study of mutated epithelial cells, and they also have made some major breakthroughs in the research area of oncogenes and tumor suppressor genes [7] IL-6 is a kind of protein with 26KD molecular weight, and composed of 184 amino acid molecules.…”

Section: Discussionmentioning

confidence: 99%

Expression and Significance of IL-6 and bFGF in Human Tongue Squamous Cell Carcinoma

Hou¹,

He²,

Hou³

et al. 2017

JCT

View full text Add to dashboard Cite

Objective: To detect the expression and pathological significances of Interleukin-6 (IL-6) and basic fibroblast growth factor (bFGF) in tongue squamous cell carcinoma (TSCC). Methods: A tissue array was analyzed immunohistochemically. The expression levels of IL-6 and bFGF in tissues were recorded semi-quantitatively. Results: The positive expression of IL-6 in normal, benign tumor, and carcinoma groups was 12.50% ± 5.575%, 39.00% ± 1.41%, 77.26% ± 17.07% respectively, and the expression among the three groups showed significant differences (P < 0.05). The expression of bFGF in benign tumor was lower than that in normal groups and squamous cell carcinoma. The positive expression was 6.50% ± 2.12%, 23.75% ± 4.79%, 42.33% ± 29.89% respectively, and the expression among the three groups showed significant differences (P < 0.05). Furthermore, there were positive correlations between IL-6 and bFGF (P < 0.05). Conclusion: It indicates that combining immunohistochemical examination of IL-6 and bFGF has an important reference value on the pathological diagnosis of tongue squamous cell carcinoma.

show abstract

Non-smoking non-drinking elderly females: a clinically distinct subgroup of oral squamous cell carcinoma patients

Cited by 58 publications

References 13 publications

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

A role for panendoscopy? Second primary tumour in early stage squamous cell carcinoma of the oral tongue

Expression and Significance of IL-6 and bFGF in Human Tongue Squamous Cell Carcinoma

Contact Info

Product

Resources

About