Non–small cell lung cancer-derived exosomes promote proliferation, phagocytosis, and secretion of microglia via exosomal microRNA in the metastatic microenvironment

Chen, Peng; Li, Ying; Li, Rui; Xie, Yi; Jin, Yu; Wang, Minghuan; Yu, Zhiyuan; Wang, Wei; Luo, Xiang

doi:10.1016/j.tranon.2022.101594

Cited by 9 publications

(4 citation statements)

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“…The role of exosomal miRNAs in cell-cell communication is thoroughly discussed, and the validity of these elements as predictive biomarkers for cancer malignancy is explored in-depth ( 34 , 35 ). Wei Wang’s research delves into NSCLC exosomes and their role in promoting proliferation, phagocytosis, and secretion of microglia in the metastatic microenvironment via exosomal miRNAs ( 36 ), and mesenchymal stem cell-mediated tumor-targeted drug delivery therapies ( 37 ). His study revealed that human bone marrow mesenchymal stem cell (MSC)-derived exosomes, containing miRNA-425, play a role in promoting migration, invasion, and lung metastasis by down-regulating cytoplasmic polyadenylation binding protein 1 ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Zhong,

Zhao,

Zhang

et al. 2024

Front. Oncol.

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BackgroundLung cancer, characterized by its high morbidity and lethality, necessitates thorough research to enhance our understanding of its pathogenesis and discover novel therapeutic approaches. Recent studies increasingly demonstrate that lung cancer cells can modulate the tumor microenvironment, promoting tumor growth, and metastasis through the release of exosomes. Exosomes are small vesicles secreted by cells and contain a variety of bioactive molecules such as proteins, nucleic acids, and metabolites. This paper presents a comprehensive review of exosome research in lung cancer and its progress through bibliometric analysis.MethodsPublications related to exosomes in lung cancer patients were systematically searched on the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was performed using VOSviwers, CiteSpace, and the R package “Bibliometrics”. Publications were quantitatively analyzed using Microsoft Office Excel 2019. The language of publication was restricted to “English” and the search strategy employed TS=(exosomes or exosomes or exosomes) and TS=(lung cancer). The search period commenced on January 1, 2004, and concluded on November 12, 2023, at noon. The selected literature types included Articles and Reviews.ResultsThe study encompassed 1699 papers from 521 journals across 71 countries and 2105 institutions. Analysis revealed a consistent upward trend in lung cancer exosome research over the years, with a notable surge in recent times. This surge indicates a growing interest and depth of inquiry into lung cancer exosomes. Major research institutions in China and the United States, including Nanjing Medical University, Shanghai Jiao Tong University, Chinese Academy Of Sciences, and Utmd Anderson Cancer Center, emerged as crucial research hubs. The annual publication count in this field witnessed a continuous rise, particularly in recent years. Key terms such as lung cancer, non-small cell lung cancer (NSCLC), microvesicles, intercellular communication, exosomal miRNAs, and oncology dominated the research landscape. Fields like cell biology, biochemistry, biotechnology, and oncology exhibited close relation with this research. Clotilde Théry emerged as the most cited author in the field, underlining her significant contributions. These results demonstrate the broad impact of exosome research in lung cancer, with key terms covering not only disease-specific aspects such as lung cancer and NSCLC but also basic biological concepts like microvesicles and intercellular communication. Explorations into exosomal microRNAs and oncology have opened new avenues for lung cancer exosome research. In summary, lung cancer exosome research is poised to continue receiving attention, potentially leading to breakthroughs in treatment and prevention.ConclusionPublications on lung cancer exosomes show a rising trend year by year, with China and the United States ranking first and second in terms of the number of publications. However, there is insufficient academic learning cooperation and exchanges between the two sides, and Chinese universities account for a large proportion of research institutions in this field. Jing Li is the most productive author, Clotilde Théry is the most co-cited author, and Cancers is the journal with the highest number of publications. The current focus in the field of lung cancer exosomes is on biomarkers, liquid biopsies, immunotherapy, and tumor microenvironment.

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Section: Discussionmentioning

confidence: 99%

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Zhong,

Zhao,

Zhang

et al. 2024

Front. Oncol.

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“…The presence of unique surface proteins in exosomes provides valuable clues to their cellular origin, thus assisting in pinpointing preferred metastatic destinations [115]. Lung cancer-derived exosomes have been observed to compromise the integrity of the blood-brain barrier, instigating microglia activation [116]. This underscores their significance beyond mere diagnostic or prognostic markers.…”

Section: Exosomes and Non-code Rnamentioning

confidence: 99%

Exploring the Molecular Tumor Microenvironment and Translational Biomarkers in Brain Metastases of Non-Small-Cell Lung Cancer

Wen,

Yu,

Liu

et al. 2024

IJMS

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Brain metastases represent a significant clinical challenge in the treatment of non-small-cell lung cancer (NSCLC), often leading to a severe decline in patient prognosis and survival. Recent advances in imaging and systemic treatments have increased the detection rates of brain metastases, yet clinical outcomes remain dismal due to the complexity of the metastatic tumor microenvironment (TME) and the lack of specific biomarkers for early detection and targeted therapy. The intricate interplay between NSCLC tumor cells and the surrounding TME in brain metastases is pivotal, influencing tumor progression, immune evasion, and response to therapy. This underscores the necessity for a deeper understanding of the molecular underpinnings of brain metastases, tumor microenvironment, and the identification of actionable biomarkers that can inform multimodal treatment approaches. The goal of this review is to synthesize current insights into the TME and elucidate molecular mechanisms in NSCLC brain metastases. Furthermore, we will explore the promising horizon of emerging biomarkers, both tissue- and liquid-based, that hold the potential to radically transform the treatment strategies and the enhancement of patient outcomes.

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“…Chen et al [128] found that A549 cells-derived exosomes were taken up by microglia HMC3 cells. Microglia are immune innate cells in the central nervous system and are reported to be enriched in brain tumors.…”

Section: Regulation Of Immune Responsementioning

confidence: 99%

The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression

Martinez-Espinosa,

Serrato,

Ortiz-Quintero

2023

Biomolecules

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The high mortality from lung cancer is mainly attributed to the presence of metastases at the time of diagnosis. Despite being the leading cause of lung cancer death, the underlying molecular mechanisms driving metastasis progression are still not fully understood. Recent studies suggest that tumor cell exosomes play a significant role in tumor progression through intercellular communication between tumor cells, the microenvironment, and distant organs. Furthermore, evidence shows that exosomes release biologically active components to distant sites and organs, which direct metastasis by preparing metastatic pre-niche and stimulating tumorigenesis. As a result, identifying the active components of exosome cargo has become a critical area of research in recent years. Among these components are microRNAs, which are associated with tumor progression and metastasis in lung cancer. Although research into exosome-derived microRNA (exosomal miRNAs) is still in its early stages, it holds promise as a potential target for lung cancer therapy. Understanding how exosomal microRNAs promote metastasis will provide evidence for developing new targeted treatments. This review summarizes current research on exosomal miRNAs’ role in metastasis progression mechanisms, focusing on lung cancer.

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Non–small cell lung cancer-derived exosomes promote proliferation, phagocytosis, and secretion of microglia via exosomal microRNA in the metastatic microenvironment

Cited by 9 publications

References 59 publications

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023)

Exploring the Molecular Tumor Microenvironment and Translational Biomarkers in Brain Metastases of Non-Small-Cell Lung Cancer

The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression

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