Non-small-cell lung cancer

Goldstraw, Peter; Ball, David; Jett, James R.; Chevalier, Thierry Le; Lim, Eric; Nicholson, Andrew G.; Shepherd, Frances A.

doi:10.1016/s0140-6736(10)62101-0

Cited by 629 publications

(473 citation statements)

References 120 publications

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“…Almost 80% of lung cancers are non-small cell lung cancers (NSCLCs) [2] . Despite recent advancements in clinical and experimental oncology, the prognosis of patients with NSCLC remains poor, with a 5-year overall survival rate of approximately 11% [3] .…”

Section: Introductionmentioning

confidence: 99%

The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer

Zhang

Hou

et al. 2017

Acta Pharmacol Sin

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Long non-coding RNAs (lncRNAs) are associated with the occurrence, development and prognoses of non-small cell lung cancer (NSCLC). In the present study, we investigated the functional mechanisms of the lncRNA XIST in two human NSCLC cell lines, A549 and NCI-H1299. In all the 5 NSCLC cell lines (NL9980, NCI-H1299, NCI-H460, SPC-A-1 and A549) tested, the expression levels of XIST were significantly elevated, as compared with those in normal human bronchial epithelial cell line BEAS-2B. In A549 and NCI-H1299 cells, knockdown of XIST by siRNA significantly inhibited the cell proliferation, migration and invasion, and promoted cell apoptosis. Furthermore, XIST knockdown elevated the expression of E-cadherin, and suppressed the expression of Bcl-2. Moreover, knockdown of XIST significantly suppressed the tumor growth in NSCLC A549 xenograft mouse model. Bioinformatic analysis and luciferase reporter assays revealed that XIST was negatively regulated by miR-449a. We further identified reciprocal repression between XIST and miR449a, which eventually influenced the expression of Bcl-2: XIST functioned as a miRNA sponge of miR-449a, which was a negative regulator of Bcl-2. These data show that expression of the lncRNA XIST is associated with an increased growth rate and metastatic potential in NSCLC A549 and NCI-H1299 cells partially through miR-449a, and suggest that XIST may be a potential prognostic factor and therapeutic target for patients with NSCLC.

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Section: Introductionmentioning

confidence: 99%

The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer

Zhang

Hou

et al. 2017

Acta Pharmacol Sin

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“…As the leading cause of cancer-related mortality globally, the annual burden of lung cancer is larger than that of any other cancers, for which more than 85% of those cases are currently classified as NSCLC (15)(16)(17). Despite recent advances in diagnosis and treatment, the predicted 5-year survival rate is only 15.9% which has only marginally improved during the past decades (18).…”

Section: Discussionmentioning

confidence: 99%

Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer

Wang

Jiang

et al. 2016

J. Thorac. Dis.

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Background: A retrospective analysis of patients undergoing cancer surgery suggested that using local anesthetics could reduce cancer recurrence and improve survival rate. Previous studies have indicated that local anesthetics may induce apoptosis in several kinds of cells in vitro, but the mechanism is unclear. Methods: Cell viability was analyzed by MTS; reactive oxygen species (ROS), mitochondrial membrane potential (MMP, ∆Ψm), cell cycle distribution, and cell apoptosis assay were detected by flow cytometry; DNA damage was measured by comet assay; cell invasion and migration were observed by microscopy; The expression level of related proteins was detected by western blot assay. Results: The results indicated that lidocaine and ropivacaine could decrease viability, induce G0/G1 phase arrest and apoptosis in human non-small cell lung cancer (NSCLC) cells A549 and H520. Invasion and migration were suppressed. Western blot indicated the related apoptotic pathways proteins changed accordingly. Additionally, lidocaine and ropivacaine downregulated ∆Ψm, provoked DNA damage, upregulated ROS production and activated mitogen-activated protein kinase (MAPK) pathways in A549 and H520 cells. Conclusions:The cytotoxic effect of amide-linked local anesthetics on NSCLC cells were mainly due to apoptosis. The antitumor mechanism of lidocaine and ropivacaine may involve apoptotic pathways and MAPK pathways.

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“…A minority of patients with lung cancer receives a treatment with curative intent, consisting of either radical surgery or definitive radiotherapy, administered either as single modality or combined with platinum-based chemotherapy [11,33,34].…”

Section: Introductionmentioning

confidence: 99%

Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities

et al. 2015

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a b s t r a c tIntroduction: The evidence on the effectiveness of rehabilitation in lung cancer patients is limited. Whole body vibration (WBV) has been proposed as an alternative to conventional resistance training (CRT). Methods: We investigated the effect of radical treatment (RT) and of two rehabilitation programmes in lung cancer patients. The primary endpoint was a change in 6-min walking distance (6MWD) after rehabilitation. Patients were randomised after RT to either CRT, WBVT or standard follow-up (CON). Patients were evaluated before, after RT and after 12 weeks of intervention. Results: Of 121 included patients, 70 were randomised to either CON (24), CRT (24) or WBVT (22). After RT, 6MWD decreased with a mean of 38 m (95% CI 22-54) and increased with a mean of 95 m (95% CI 58-132) in CRT (p < 0.0001), 37 m (95% CI −1-76) in WBVT (p = 0.06) and 1 m (95% CI −34-36) in CON (p = 0.95), respectively. Surgical treatment, magnitude of decrease in 6MWD by RT and allocation to either CRT or WBVT were prognostic for reaching the minimally clinically important difference of 54 m increase in 6MWD after intervention. Conclusions: RT of lung cancer significantly impairs patients' exercise capacity. CRT significantly improves and restores functional exercise capacity, whereas WBVT does not fully substitute for CRT.

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Non-small-cell lung cancer

Cited by 629 publications

References 120 publications

The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer

The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer

Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer

Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities

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