Non-selective beta-blockers for the patients with acute on chronic liver failure

The anti-inflammatory role of propranolol in cirrhosis: Preventing the inflammatory exhaustion?

“…The authors demonstrated an increased survival for the one in use of NSBB (mortality 34.1% vs. 24.4%, p = 0.048), and moreover, they found a lower white blood cell count (WBC) comparing to the group without NSBB, reflecting less systemic inflammation. However, a recent letter was published by Ustundag and Saritas criticizing some aspects of Mookerjee and co-workers study [2]. They do not agree with the fact that WBC could reflect inflammatory response, arguing that lower WBC could be consequence of higher rate of hypersplenism, present among NSBB users.…”