Non respiratory symptoms in asthma as possible predictors of exacerbations

Liccardi, Gennaro; Baldi, G.; Berra, A; Carpentieri, Emanuela; Cutajar, M.; D’Amato, Maria; Donno, Mario Del; Prato, Bruno del; Folletti, Ilenia; Gani, Federica; Gargano, Domenico; Giannattasio, Domenico; Giovannini, M; Infantino, Antonio; Lombardi, Carlo; Schiavo, M. Lo; Madonna, Francesco; Maniscalco, Mauro; Meriggi, A; Milanese, Manlio; Montera, Carmen; Pio, Antonio; Russo, María Julieta; Salzillo, Antonello; Scavalli, P.; Scichilone, Nicola; Sposato, Bruno; Stanziola, Anna Agnese; Starace, Antonio; Vatrella, Alessandro; D’Amato, Gennaro; Passalacqua, Giovanni

doi:10.1016/j.jaip.2015.04.011

Cited by 10 publications

(12 citation statements)

References 11 publications

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“…Indirectly, the results of our study [9] confirmed the assumption that cholinergic pathway is a determinant broncho-constrictor at least in a group of asthmatic patients. In fact, some n-RSs that precede the appearance of an asthma attack are clearly the expression of an increased cholinergic tone.…”

Section: To the Editorsupporting

confidence: 87%

“…We have recently shown that about 63% of asthmatics reported at least one non-respiratory symptom (n-RS) before an asthma attack [9]. Some n-RSs observed in our study are the consequence of an imbalance between sympathetic/parasympathetic systems, with a prevalence of cholinergic tone.…”

Section: To the Editorsupporting

confidence: 51%

“…dry mouth, sweating, heartburn, and abdominal pain) or associated with this condition (e.g. psychological stress) could be present together with parasympathetic-associated RSs such as those elicited by airway narrowing [9].…”

Section: To the Editormentioning

confidence: 99%

“…According to our previous study [9], a simple question exploring the presence of vagal-related n-RSs during the collection of anamnestic data could help to identify asthmatics with imbalance between sympathetic and parasympathetic systems who could benefit from further diagnostic evaluation of vagal tone. Since the degree of cholinergic tone is likely to be different among asthmatics, we think it is not possible to rule out that the effectiveness of anticholinergic agents such as tiotropium could be greater in patients with an increased degree of cholinergic tone.…”

Section: To the Editormentioning

confidence: 99%

See 3 more Smart Citations

Can a better patient phenotyping predict the efficacy of tiotropium in asthmatic adolescents?

Liccardi

Calzetta

Salzillo

et al. 2017

Expert Opinion on Pharmacotherapy

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Section: To the Editorsupporting

confidence: 87%

Section: To the Editorsupporting

confidence: 51%

Section: To the Editormentioning

confidence: 99%

Section: To the Editormentioning

confidence: 99%

See 2 more Smart Citations

Can a better patient phenotyping predict the efficacy of tiotropium in asthmatic adolescents?

Liccardi

Calzetta

Salzillo

et al. 2017

Expert Opinion on Pharmacotherapy

Self Cite

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“…Stressful events can trigger asthma exacerbations, but could also contribute to the development of incident asthma. However, only few studies have investigated the association between stressful events and adult asthma prospectively [20]. Likewise, stress-related personality traits (e.g., neuroticism and extraversion) may increase asthma risk [21].…”

Section: The Impact Of Social Network On Asthma/asthma Controlmentioning

confidence: 99%

The WEB-based Asthma Control: an intriguing connection or a dangerous hazard?

Lombardi

Passalacqua

Canonica

2015

asthma res and pract

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Globally, an estimated 300 million people have asthma, presenting a considerable and increasing burden of disease for healthcare systems, families, and patients themselves. Despite two decades of guidelines, asthma seems to remain not optimally controlled in a substantial proportion of people. The achievement of asthma control is the result of the interaction among different variables concerning the disease pattern and patients’ and physicians’ knowledge and behavior. It is well known that adherence to treatment increases in parallel to patient education. There is now a growing interest in the use of digital information technologies to promote asthma control and improve outcomes. Mobile health, or mHealth, refers to mobile devices, medical sensors, and communication technologies that can enhance chronic disease care and monitoring. Aim of this review was to evaluate the web resources nowadays available and to analyze the published studies about the web-based instruments used to improve asthma knowledge, control asthma outcomes. In general, studies revealed that the technology is well accepted. Interactive asthma technology may be, in addition, of help in reaching populations difficult to reach, such as inner city populations. The number of tools and apps available continues to increase, and agencies such as the FDA, become involved in their regulation, thus the mHealth landscape will continue to evolve. Although asthma tools and apps have great potential to improve care for asthma, the proof of data reproducibility, the demonstration of effectiveness, and the privacy issues still represent the major technical problems.

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