Non-protected fluid room temperature phosphorescence of several naphthalene derivatives

Li, Long-Di; Zhao, Yu; Wu, Yingguang; Tong, Aijun

doi:10.1016/s0039-9140(97)00378-0

Cited by 36 publications

(14 citation statements)

References 9 publications

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“…Later studies [10] have demonstrated that RTP emission of some compounds can be directly induced in aqueous solutions assisted only by addition of relatively high concentrations of a heavy atom perturber and sodium sulfite as chemical deoxygenator [11,12,13,14,15,16,17,18,19]. This type of RTP emission has been called heavy atom induced -room temperature phosphorescence (HAI-RTP) [10,11,12,13,14,15,16,17,18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Díaz¹,

Terrones

Segura‐Carretero³

et al. 2004

Analytical and Bioanalytical Chemistry

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We present results from a comparative study of three proposed phosphorimetric methods for determination of naphazoline (NPZ) in solution. The first method is based on use of micelles to stabilize phosphorescence signals in solutions at room temperature (MS-RTP). The second is based on the use of a heavy atom salt and sodium sulfite as an oxygen scavenger to obtain room-temperature phosphorescence (HAI-RTP) in solution. The last method employs an optical sensor for NPZ based on the phosphorescent properties of the analyte on a solid sensor phase. The aim of this work was to compare time consumption, simplicity, sensitivity, selectivity, detection, and quantification limits for use of these three phosphorimetric methods to determine naphazoline in pharmaceutical preparations. The most simple, sensitive, and reproducible of the three methods for naphazoline analysis is the HAI-RTP method. Detection limits are 4.9, 1.7, and 9.4 ng mL(-1), respectively, for the MS-RTP, HAI-RTP, and optosensor methods.

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Section: Introductionmentioning

confidence: 99%

“…This type of RTP emission has been called heavy atom induced -room temperature phosphorescence (HAI-RTP) [10,11,12,13,14,15,16,17,18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Díaz¹,

Terrones

Segura‐Carretero³

et al. 2004

Analytical and Bioanalytical Chemistry

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“…On the other hand, recent studies have demonstrated that RTP emission of naphthalene derivatives and heterocyclic compounds can be directly induced in aqueous solutions by addition of high concentrations of a heavy atom perturber and sodium sulfite as a chemical deoxygenator [9,10,11,12]. This methodology, named heavy atom induced room temperature phosphorescence (HAI-RTP), has been applied to the determination of naphazoline, nafronyl, or propranolol in pharmaceutical preparations [13,14,15] and some pesticides in vegetables matrices [16,17].…”

Section: Introductionmentioning

confidence: 99%

Sensitive and simple determination of the vasodilator agent dipyridamole in pharmaceutical preparations by phosphorimetry

Salinas-Castillo

Segura‐Carretero

Fernández‐Gutiérrez³

2003

Analytical and Bioanalytical Chemistry

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The applicability of heavy atom-induced room-temperature phosphorescence to pharmaceutical samples is demonstrated in this work. Thus a new, simple, rapid, and selective phosphorimetric method for dipyridamole determination is proposed. The phosphorescence signals are a consequence of intermolecular protection when analytes are exclusively in the presence of heavy atom salts and sodium sulfite as an oxygen scavenger to minimize RTP quenching. The determination was performed in 0.1 mol L(-1) thallium(I) nitrate and 8 mmol L(-1) sodium sulfite at a measurement temperature of 20 degrees C. The phosphorescence intensity was measured at 635 nm, with excitation at 305 nm. Phosphorescence was easily developed; a linear concentration range was obtained between 0 and 100 ng mL(-1) with a detection limit of 940 ng L(-1), an analytical sensitivity of 2.5 ng mL(-1), and a standard deviation of 2.7% at 60 ng mL(-1) concentration. The method has been successfully applied to the analysis of dipyridamole in a unique Spanish commercial formulation containing 100 ng mL(-1) per capsule. The recovery was 101.6% with 6.5% standard deviation of analytical measurement. The method using the standard addition methodology has been validated.

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“…In some works by foreign authors [2][3][4][5], active phosphorescing components of different medicinal preparations were determined using the room-temperature phosphorescence (RTP) method. However, the possibility of determining these compounds in combined preparations in the presence of many other phosphorescing components has not been examined.…”

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confidence: 99%

Phosphorimetric Determination of Active Components in Medicinal Preparations

2005

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Every year, the discovery and elimination of adulterated medicinal preparations becomes a more difficult and important problem. Adulterated preparations are hazardous because their can contain no active (working) components or these components can occur in the amounts insufficient for the therapeutic effect. Because of the growth the amount of adulterated products in the market, the development of rapid methods for the analytical control of pharmaceutical preparations is an important problem.Currently the medicinal remedies Naphazoline, Naproxen, Propranolol, and Terbinafine (scheme) are identified using molecular optical spectroscopy, highperformance liquid chromatography, and test methods (Table 1). Titration (for pure substances) and high-performance liquid chromatography (for combined preparations) are commonly used for the quantitative determination [1]. Similar data have been reported in some pharmacopoeia articles of Russian companies. Titration is a rather time-consuming and laborious technique, and chromatographic methods involve relatively complex preliminary sample preparation.In recent years, luminescence analytical methods found wide application for the determination of active components in medicinal preparations. The determination of the target component in the presence of fluorescing impurities by conventional fluorimetric procedures is commonly complicated by spectral overlaps, the absorption of the fluorescence of one component by the others, etc. In our opinion, a more reasonable technique consists in the determination of naphthalene derivatives and some other phosphorescing compounds on the basis of phosphorescence measurements, because the triplet states of the analyte molecules are more characteristic in comparison with the singlet states. The selectivity of the determination is substantially improved by the time selection of the fluorescence analytical signal.In some works by foreign authors [2-5], active phosphorescing components of different medicinal preparations were determined using the room-temperature phosphorescence (RTP) method. However, the ARTICLES Abstract -The use of room-temperature phosphorescence was proposed for the determination of active components containing naphthalene rings in their structures in medicinal preparations. It was demonstrated that this method can be used for the determination of active components in combined preparations.

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Non-protected fluid room temperature phosphorescence of several naphthalene derivatives

Cited by 36 publications

References 9 publications

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Sensitive and simple determination of the vasodilator agent dipyridamole in pharmaceutical preparations by phosphorimetry

Phosphorimetric Determination of Active Components in Medicinal Preparations

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