Non-Primary cervical adenocarclnomas

Mulvany, Nicholas J.; Nirenberg, Alexander; Öster, Andrew G.

doi:10.1080/00313029600169214

Cited by 26 publications

(17 citation statements)

References 11 publications

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“…It is very important to identify the presence of cervical tumor activity and determine its origin because this information will have implications for the patient's diagnosis, treatment and prognosis 3,14 . The detailed histopathological features of the lesion and judicious use of immunohistochemical techniques allow us to determine the true origin of the metastatic disease 15 . Our objectives in this report were to describe the clinical behavior of the cases we saw and treated at INCan and to conduct a systematic review allowing us to establish the behavior of the most frequent extragenital tumors metastatic to the uterine cervix, and attempt to generate diagnostic and treatment guidelines.…”

Section: Introductionmentioning

confidence: 99%

Adenocarcinoma metastatic to the uterine cervix: A case series

Pérez-Montiel¹,

Serrano-Olvera

Salazar

et al. 2012

J of Obstet and Gynaecol

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Section: Introductionmentioning

confidence: 99%

Adenocarcinoma metastatic to the uterine cervix: A case series

Pérez-Montiel¹,

Serrano-Olvera

Salazar

et al. 2012

J of Obstet and Gynaecol

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“…The uterine cervix is an uncommon site for metastases or secondary involvement by tumor (1)(2)(3)(4). Three typical patterns of tumor spread to the cervix are recognized: (i) direct extension; (ii) paracervical soft-tissue involvement; and (iii) vascular or lymphatic permeation.…”

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confidence: 99%

Fallopian Tube High-grade Serous Carcinoma With Intramucosal Spread and Presenting as a Malignancy on Pap Smear

Kos

Broaddus

Djordjevic

2014

International Journal of Gynecological Pathology

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For the first time, we report a case of a primary high-grade serous carcinoma of the fallopian tube in a 69-yr-old woman with intraepithelial involvement of endocervical glands. The patient had a remote history of tubal ligation and no known personal or family history of breast or gynecologic cancer. She initially presented with an abnormal Pap smear, and, on a subsequent endometrial curettage, detached fragments of high-grade adenocarcinoma were identified. Upon hysterectomy and bilateral salpingoophorectomy, invasive high-grade serous carcinoma was found in the proximal stump of a ligated fallopian tube. Morphologically identical tumor extensively involved the endocervical glands. A single focus of malignant cells was also found at the surface of the lower uterine segment endometrium. By immunohistochemistry, the tumors in the fallopian tube and in the cervix showed the same immunopheonotype. This included diffuse staining for WT-1, PAX-8, p16, and p53, and focal staining for the monoclonal carcinoembryonic antigen. The estrogen receptor was negative. Human papillomavirus-in situ hybridization was also negative. The focus of intramucosal tumor within the endometrium was similarly positive for WT-1 and p53 and negative for the estrogen receptor. The patient was subsequently treated with 6 cycles of carboplatinum and taxol. She remains well with no evidence of recurrent disease. The phenomenon of intramucosal tumor spread to the cervix mimicking primary invasive or in situ cervical adenocarcinoma may present a diagnostic challenge for the pathologist, requiring consideration of an appropriately wide differential diagnosis when interpreting cervical cytology and endocervical and endometrial biopsies.

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“…All have concluded that their presence within the endocervical canal without endocervical tissue invasion is associated with a less aggressive behavior and that such involvement be regarded as Stage I disease (22,23) . Mulvany et al concluded that cervical implantation occurs exclusively following previous cervical instrumentation and that prognosis was dependent on the histoprognostic features of the primary tumor (24) . In contrast, cervical lymphovascular or stromal metastases reflected disseminated pelvic or abdominal malignancy with a poor prognosis (24) .…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological study of the pattern and significance of cervical involvement in cases of endometrial adenocarcinoma

Jordan¹,

Al-Nafussi²

2002

Int J Gynecol Cancer

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Jordan LB, Al-Nafussi A. Clinicopathological study of the pattern and significance of cervical involvement in cases of endometrial adenocarcinoma. Int J Gynecol Cancer 2002;12:42-48.The pattern of cervical involvement in 107 endometrial adenocarcinomas was assessed. The cervix was involved in 29%, higher than noted in previous studies. In 40.6%, the lesion was confined to surface endocervical epithelium only; the remainder had cervical stromal involvement. In the majority only small areas within the circumference of the cervix were affected, indicating a need for adequate tissue sampling. In some cases, malignant epithelium was found as a "migrant" within the endocervical canal, entrapped within cervical mucus or applied to surface epithelium, supporting the concept that endometrial cancer spreads by surface contiguity or implantation rather than by deep tissue planes or via lymphatic channels.Our findings reinforce the view that high-grade lesions and histological subtypes such as uterine serous papillary carcinoma are associated with a later presentation, higher stage and poorer prognosis. We have identified atypical changes in endocervical epithelium that may be misinterpreted as cervical involvement, particularly in the form of atypical reserve cell hyperplasia with a micropapillary pattern that may reflect a reaction to the presence of tumor. It is our assertion that the presence of tumor "migrants", and not endocervical surface atypia, is an indicator of increased probability of cervical involvement by endometrial adenocarcinoma (P = 0.015).

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Non-Primary cervical adenocarclnomas

Cited by 26 publications

References 11 publications

Adenocarcinoma metastatic to the uterine cervix: A case series

Adenocarcinoma metastatic to the uterine cervix: A case series

Fallopian Tube High-grade Serous Carcinoma With Intramucosal Spread and Presenting as a Malignancy on Pap Smear

Clinicopathological study of the pattern and significance of cervical involvement in cases of endometrial adenocarcinoma

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