Non-Polio Enterovirus Disease in the United States, 1971–1975

Morens, David M.; Zweighaft, Ronald M.; Bryan, John M

doi:10.1093/ije/8.1.49

Cited by 28 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…E33 is an uncommon enterovirus serotype with few reports in the literature [3][4][5][6][7][8][9][10][11][12][13]. Only 6 E33 isolates had been previously identified in New Zealand.…”

Section: Discussionmentioning

confidence: 99%

An Echovirus Type 33 Winter Outbreak in New Zealand

Huang¹,

Carr²,

Nix³

et al. 2003

Clinical Infectious Diseases

View full text Add to dashboard Cite

Echovirus type 33 (E33) is a relatively uncommon enterovirus. An E33 outbreak during the winter of 2000 in New Zealand led to 75 virologically-confirmed cases of E33 infection (2.6 cases per 100,000 individuals). Sixty-six (88%) of the 75 patients were aged <30 years, with the highest rates of infection recorded in Maori and Pacific ethnic groups. Overall, 47 (84%) of 56 patients whose cases were analyzed had either aseptic meningitis or encephalitis. Central nervous system involvement was more common after infancy (43 of 45 non-infant patients vs. 4 of 11 infants [relative risk, 2.6; 95% CI, 1.5-4.3]). Two infants died, including a neonate with fulminant hepatitis. Independent of symptom duration, neutrophil-predominant pleocytosis was detected in 17 (41%) of 41 cerebrospinal fluid specimens. Virus isolates could not be definitively typed by antibody neutralization testing but were identified as E33 by partial sequencing of the VP-1 capsid gene. The isolates were closely related to strains from Australia and Oman. Molecular typing, together with a serotype-specific E33 PCR, improved the speed and effectiveness of the outbreak investigation.

show abstract

“…E33 is an uncommon enterovirus serotype with few reports in the literature [3][4][5][6][7][8][9][10][11][12][13]. Only 6 E33 isolates had been previously identified in New Zealand.…”

Section: Discussionmentioning

confidence: 99%

An Echovirus Type 33 Winter Outbreak in New Zealand

Huang¹,

Carr²,

Nix³

et al. 2003

Clinical Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…While continued monitoring may identify pathologies associated with BDEV, our findings so far suggest that BDEV infections in bottlenose dolphins, like those in several other species, are largely subclinical. In humans, shedding of EV does not necessarily indicate disease, because most infections and subsequent shedding are asymptomatic (Morens et al, 1979; Moore, 1982). …”

Section: Discussionmentioning

confidence: 99%

“…Several cross-reactive EV types typically co-circulate in humans (Morens et al, 1979; Moore, 1982). Since this is the only known dolphin EV type, we are unable to determine specificity of the assay and can not evaluate heterotypic responses that have been reported in humans (Swanink et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

New recognition of Enterovirus infections in bottlenose dolphins (Tursiops truncatus)

Nollens

Rivera

Palacios

et al. 2009

Veterinary Microbiology

View full text Add to dashboard Cite

An enterovirus was cultured from an erosive tongue lesion of a bottlenose dolphin (Tursiops truncatus). The morphology of virions on negative staining electron microscopy was consistent with those of enteroviruses. Analysis of 2613 bp of the polyprotein gene identified the isolate as a novel enterovirus strain, tentatively named bottlenose dolphin enterovirus (BDEV), that nests within the species Bovine enterovirus. Serologic evidence of exposure to enteroviruses was common in both free ranging and managed collection dolphins. Managed collection dolphins were more likely to have high antibody levels, although the highest levels were reported in free ranging populations. Associations between enterovirus antibody levels, and age, sex, complete blood counts, and clinical serum biochemistries were explored. Dolphins with higher antibody levels were more likely to be hyperproteinemic and hyperglobulinemic.

show abstract

“…Coxsackievirus contains 23 serotypes in group A and 6 in group B, and echovirus contains 33 [1]. Even though the majority of nonpolio enteroviral infections are asymptomatic, they often cause a wide spectrum of human diseases such as common cold, aseptic meningitis, encephalitis, myocarditis, diabetes, diarrhea, rash, or acute hemorrhagic conjunctivitis [2][3][4][5]. In fact, they are one of the most common causes of fever in children, particularly during summer and fall [6,7].…”

mentioning

confidence: 99%

Characterization of Nonpolio Enteroviruses Recovered from Patients with Aseptic Meningitis in Korea

et al. 2005

View full text Add to dashboard Cite

Objectives: We attempted to characterize nonpolio enteroviruses recovered from Korean patients with aseptic meningitis. Methods: We performed RT-PCR on the 5′-nontranslated region using clinical specimens. Infectious clinical isolates were amplified by infecting Vero cells with RT-PCR-positive clinical specimens. We then investigated the direct effect in primary neuronal cells or cardiomyocytes following virus infection. Results: Total 12 clinical isolates were subtypically analyzed by both RT-PCR/sequencing comparison of the VP-1 region and neutralization assay. 43-2, 43-2S, 57 and 58 were found to be coxsackievirus B1 (CVB1), 312 to be CVB5, 14-2S and 327 to be echovirus 6, 165 to be echovirus 9, 337 to be echovirus 11, and 270 to be echovirus 30. All the clinical isolates tested showed profound cytotoxicity to various degrees in the primary neuronal cells within 24 h postinfection at 10 MOI. By contrast, a significant cytopathic effect was observed in the primary cardiomyocytes at 3–5 days postinfection at 50 MOI. Conclusions: The present study suggests that the clinical isolates recovered from Korean patients belonged to different CVB or echovirus serotypes and that these viruses showed diversities in their virulence in primary neuronal cells and cardiomyocytes.

show abstract

Non-Polio Enterovirus Disease in the United States, 1971–1975

Cited by 28 publications

References 0 publications

An Echovirus Type 33 Winter Outbreak in New Zealand

An Echovirus Type 33 Winter Outbreak in New Zealand

New recognition of Enterovirus infections in bottlenose dolphins (Tursiops truncatus)

Characterization of Nonpolio Enteroviruses Recovered from Patients with Aseptic Meningitis in Korea

Contact Info

Product

Resources

About