Non-Pharmacological Interventions for Patients with Mild Cognitive Impairment: A Meta-Analysis of Randomized Controlled Trials of Cognition-Based and Exercise Interventions

Abstract

Both of cognition-based intervention and physical exercise had the potential to improve global cognitive function. Weak evidence of improvements was also observed for the domains of executive function and delayed memory following cognition-based intervention. Nevertheless, future standard RCTs are still needed to identify the clinical value of our results.

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

“…109 Another meta-analysis involving 14 randomized controlled trials (RCTs) found exercise had a very small significant effect on improving verbal fluency and no other significant effects. 110 Wang et al 111 found an effect of exercise on global cognitive function. Many of these studies were conducted over relatively short periods.…”

Group- and Home-Based Cognitive Intervention for Patients with Mild Cognitive Impairment: A Randomized Controlled Trial

“…Although follow-up evaluations are important because aMCI is a degenerative condition in many individuals, they have not been conducted in many studies [8]. Further, most of the studies had a small sample size [8,9,10]. There is a lack of randomized placebo-controlled trials and standardization of training programs, with great variability in study design [8,9].…”

“…Further, most of the studies had a small sample size [8,9,10]. There is a lack of randomized placebo-controlled trials and standardization of training programs, with great variability in study design [8,9]. The efficacy of cognitive intervention in MCI remains to be verified in quality trials in large samples.…”

“…Results of studies on cognitive intervention for aMCI were inconsistent [8,9]. Objective and subjective measures of memory, quality of life (QOL) and mood have demonstrated significant improvements following cognitive intervention in half of the reviewed studies [8].…”

Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA)

“…[100]. In a recent meta-analysis, cognition-based intervention was associated with improved global cognitive function in people with MCI and weak evidence of improvements in the specific domains of executive function and delayed memory [101]. However, these types of intervention rely on the resources to implement and sustain them in practice, and the field has a need to develop evidence-based training which can be sustained by the individuals.…”