The development of delirium is highly probable in COVID-19 patients, and its management is much more difficult than other diseases. Nurses have important roles in the management of delirium that may develop in COVID-19 patients. The aim of this paper was to review the literature regarding non-pharmacological interventions in intensive care units (ICUs) to prevent delirium in COVID-19 patients. The terms used in the literature search were 'intensive care' or 'critical care' including their abbreviations, as well as 'delirium,' 'intervention,' 'approach, with Turkish and English words. The literature was scanned using the keywords based on the Medical Subject Headings (MeSH) and Embase Tree (EMTREE) from the databases of Cochrane, CINAHL, PsyInfo PubMed, and EMBASE. A total of 63 studies were included in the review. In this paper, it was found that non-pharmacological interventions had an important place in delirium management; however, the transmission way of COVID-19 via droplets prevents many non-pharmacological attempts. First and foremost, among these interventions is the termination of the sedating drug, preventing isolation, ensuring that the patient spends time with visitors, and weaning from mechanical ventilation. In COVID-19 patients, the latest technology may be used to help prevent social isolation. Based on the findings of this literature review, we recommend a patient-centered approach in the management of delirium in COVID-19 patients and a revision of current strategies in accordance with the profiles of the patient and the disease. It is recommended to raise awareness on interventions for delirium syndrome that may cause problems for nurses regarding COVID-19. .