We study the vacuum fluctuations of a quantum scalar field in the presence of a thin and inhomogeneous flat mirror, modelled with a delta potential. Using Heat-Kernel techniques, we evaluate the Euclidean effective action perturbatively in the inhomogeneities (nonperturbatively in the constant background). We show that the divergences can be absorbed into a local counterterm, and that the remaining finite part is in general a nonlocal functional of the inhomogeneities, which we compute explicitly for massless fields in D = 4 dimensions. For time-independent inhomogeneities, the effective action gives the Casimir self-energy for a partially transmitting mirror. For time-dependent inhomogeneites, the Wick-rotated effective action gives the probability of particle creation due to the dynamical Casimir effect.