Non-peptide oxytocin agonists

Pitt, Gary R. W.; Batt, Andrzej R.; Haigh, R. M.; Penson, Andrew M.; Robson, Peter A.; Rooker, David P.; Tartar, André; Trim, Julie E.; Yea, Christopher; Roe, Michael B.

doi:10.1016/j.bmcl.2004.04.107

Cited by 58 publications

(27 citation statements)

References 13 publications

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“…The benefit of non-peptide agonists lies in the potential for increased stability, central penetration and oral bioavailability, making the agonist more amenable to classical routes of pharmacotherapeutic administration (Ashworth et al, 2006; Pitt et al, 2004). In addition, the increased epitope specificity possible with small, non-peptide agonists potentially allows for increased selectivity for the OTR over the structurally similar vasopressin receptors (Hawtin et al, 2001).…”

Section: Therapeutic Strategies For Targeting the Ot Systemmentioning

confidence: 99%

“…However, the effects of WAY-267464 have not yet been reported in paradigms assessing social cognition. Ferring Pharmaceuticals also developed a potent nonpeptide agonist, which maximally stimulates the OTR to the same degree as OT and is 25 times for selective for the OTR than any other receptors in the family (Pitt et al, 2004). Behavioral efficacy of the Ferring agonist, though, has yet to be demonstrated.…”

Section: Therapeutic Strategies For Targeting the Ot Systemmentioning

confidence: 99%

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The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies

Modi

Young

2012

Hormones and Behavior

194

162

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Animal models and behavioral paradigms are critical for elucidating the neural mechanism involved in complex behaviors, including social cognition. Both genotype and phenotype based models have implicated the neuropeptide oxytocin (OT) in the regulation of social behavior. Based on the findings in animal models, alteration of the OT system has been hypothesized to play a role in the social deficits associated with autism and other neuropsychiatric disorders. While the evidence linking the peptide to the etiology of the disorder is not yet conclusive, evidence from multiple animal models suggest modulation of the OT system may be a viable strategy for the pharmacological treatment of social deficits. In this review, we will discuss how animal models have been utilized to understand the role of OT in social cognition and how those findings can be applied to the conceptualization and treatment of the social impairments in ASD. Animal models with genetic alterations of the OT system, like the OT, OT receptor and CD38 knock-out mice, and those with phenotypic variation in social behavior, like BTBR inbred mice and prairie voles, coupled with behavioral paradigms with face and construct validity may prove to have predictive validity for identifying the most efficacious methods of stimulating the OT system to enhance social cognition in humans. The widespread use of strong animal models of social cognition has the potential yield pharmacological, interventions for the treatment social impairments psychiatric disorders. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.

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Section: Therapeutic Strategies For Targeting the Ot Systemmentioning

confidence: 99%

Section: Therapeutic Strategies For Targeting the Ot Systemmentioning

confidence: 99%

The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies

Modi

Young

2012

Hormones and Behavior

194

162

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“…For example, oxytocin receptor agonists have been developed that can be delivered orally and stimulate the oxytocin receptor 137,138 , and there is evidence that melanocortin 4 receptor agonists stimulate the central release of oxytocin in rats 139 . Given the evidence presented here of the potentially broad and diverse impact of oxytocin across a range of neuropsychiatric disorders, drug development along these lines would presumably be advantageous for a wide number of patients.…”

Section: Clinical Implications and Limitationsmentioning

confidence: 99%

The Role of Oxytocin in Psychiatric Disorders

Cochran

Fallon

Hill

et al. 2013

Harvard Review of Psychiatry

224

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Oxytocin is a peptide hormone integral in parturition, milk let-down, and maternal behaviors that has been demonstrated in animal studies to be important in the formation of pair bonds and in social behaviors. This hormone is increasingly recognized as an important regulator of human social behaviors, including social decision making, evaluating and responding to social stimuli, mediating social interactions, and forming social memories. In addition, oxytocin is intricately involved in a broad array of neuropsychiatric functions, and may be a common factor important in multiple psychiatric disorders such as autism, schizophrenia, mood and anxiety disorders. This review article examines the extant literature on the evidence for oxytocin dysfunction in a variety of psychiatric disorders and highlights the need for further research to understand the complex role of the oxytocin system in psychiatric disease to pave the way for developing new therapeutic modalities. Articles were selected that involved human participants with various psychiatric disorders, either comparing oxytocin biology to healthy controls or examining the effects of exogenous oxytocin administration.

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“…Further, in human neuropsychiatric disorders characterized by impaired sociability, the roles of Oxt and Avp are being elucidated and better pharmacological agents are being developed. 189–192 …”

Section: Discussionmentioning

confidence: 99%

Neurobiology of Sociability

Caldwell

2012

Advances in Experimental Medicine and Biology

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Sociability consists of behaviors that bring animals together and those that keep animals apart. Remarkably, while the neural circuitry that regulates these two “faces” of sociability differ from one another, two neurohormones, oxytocin (Oxt) and vasopressin (Avp), have been consistently implicated in the regulation of both. In this chapter the structure and function of the Oxt and Avp systems, the ways in which affiliative and aggressive behavior are studied, and the roles of Oxt and Avp in the regulation of sociability will be briefly reviewed. Finally, work implicating Oxt and Avp in sociability in humans, with a focus on neuropsychiatric disorders will be highlighted.

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Non-peptide oxytocin agonists

Cited by 58 publications

References 13 publications

The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies

The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies

The Role of Oxytocin in Psychiatric Disorders

Neurobiology of Sociability

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