1995
DOI: 10.1006/bbrc.1995.2173
|View full text |Cite
|
Sign up to set email alerts
|

Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
18
0

Year Published

1998
1998
2014
2014

Publication Types

Select...
3
3

Relationship

0
6

Authors

Journals

citations
Cited by 23 publications
(18 citation statements)
references
References 0 publications
0
18
0
Order By: Relevance
“…They can be divided into six general classes of BB 2 receptor antagonists Jensen et al, 1993;de Castiglione and Gozzini, 1996) (Table 2). All classes are peptides or peptoid antagonists, except for class 6, which are flavone derivatives, isolated from extracts of the mulberry tree Morus bombycis (Mihara et al, 1995). These six classes include substituted substance P analogs (class 1), ]bombesin analogs (class 2), modified position 13-14 bombesin or position 26 -27 GRP analogs (class 3), desMet 14 or GRP 27 analogs (class 4), peptoids (class 5), and finally the nonpeptide analogs, kuwanon G and H (class 6) ( ]SP, not only functioned as a substance P receptor antagonist, but also inhibited both radiolabeled bombesin binding and bombesin-stimulated amylase release from guinea pig pancreatic acini, which are now known to possess only BB 2 receptors.…”
Section: Bb 2 Receptor Expressionmentioning
confidence: 99%
See 3 more Smart Citations
“…They can be divided into six general classes of BB 2 receptor antagonists Jensen et al, 1993;de Castiglione and Gozzini, 1996) (Table 2). All classes are peptides or peptoid antagonists, except for class 6, which are flavone derivatives, isolated from extracts of the mulberry tree Morus bombycis (Mihara et al, 1995). These six classes include substituted substance P analogs (class 1), ]bombesin analogs (class 2), modified position 13-14 bombesin or position 26 -27 GRP analogs (class 3), desMet 14 or GRP 27 analogs (class 4), peptoids (class 5), and finally the nonpeptide analogs, kuwanon G and H (class 6) ( ]SP, not only functioned as a substance P receptor antagonist, but also inhibited both radiolabeled bombesin binding and bombesin-stimulated amylase release from guinea pig pancreatic acini, which are now known to possess only BB 2 receptors.…”
Section: Bb 2 Receptor Expressionmentioning
confidence: 99%
“…The only nonpeptide, nonpeptoid antagonists of BB 2 receptors reported are kuwanon G and kuwanon H, two closely related flavone compounds that were isolated from the Mulberry tree, M. bomcycis (Mihara et al, 1995). Only one study (Mihara et al, 1995) has examined their ability to interact with BB 2 receptors on Swiss 3T3 cells.…”
mentioning
confidence: 99%
See 2 more Smart Citations
“…The oxygen molecule is presumably held in the pocket by weak bonds such as the bonds in the charge transfer complex postulated in the reaction mechanism of the photo-oxidative cyclization of 1 (Scheme 1). 13 Similar oxide ions also appeared in the LDI-TOF and/or MALDI-TOF mass spectra of artonin E (4) obtained from Artocarpus heterophyllus, kuwanon B (5), C (6), and G (7, hypotensive agent and antagonist of bombesin) 18,23 from Morus alba, and dihydromorusin (8), having 3-prenyl and 2'-hydroxyl groups, but not in the spectra of oxydihydromorusin (9), 2'-O-methylmorusin (10), 2',4'-di-O-methylmorusin (11), and tetrahydromorusin (12). The above data indicate that the production of the oxide ions require the 3- prenyl and 2'-hydroxyl groups in the skeleton.…”
mentioning
confidence: 97%