Abstract:Genome-wide association study (GWAS) is a fundamental step for understanding the genetic link to traits (phenotypes) of interest, such as disease, BMI and height. Typically, GWAS estimates the effect of SNP on the phenotype using a linear model by coding SNP as working code, {0, 1, 2}, according to the minor allele frequency. Looking inside the linear model, we find that the coding strategy of SNP plays a key role in detecting SNPs contributed to the phenotype. Specifically, a partial mismatch between the orde… Show more
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