Non-opioid antitussives and methadone differentially influence hippocampal long-term potentiation in freely moving rats

Krug, Manfred; Matthies, Renate; Wagner, Maria; Brödemann, Rudolf

doi:10.1016/0014-2999(93)90110-4

Cited by 23 publications

(14 citation statements)

References 30 publications

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“…The duration of both facilitation and depression was sufficiently long to be consistent with LTP/LTD of excitatory synapses (Sjöström et al, 2008). DXM, a blocker of NMDA receptors (Wong et al, 1988) and LTP formation in animal preparations (Krug et al, 1993), blocked cTBS300-induced facilitation. Since NDP relatively specifically affects L-type voltage-gated Ca 2ϩ channels (Randall and Tsien, 1997), blockade of Ca 2ϩ entry into the postsynaptic neuron via L-VGCCs is a likely explanation for polarity reversal of cTBS300-induced effects.…”

Section: ؉ Dynamics Determine the Direction Of Motor Cortical Ltp/ltmentioning

confidence: 79%

L-Type Voltage-Gated Ca²⁺Channels: A Single Molecular Switch for Long-Term Potentiation/Long-Term Depression-Like Plasticity and Activity-Dependent Metaplasticity in Humans

Wankerl¹,

Weise²,

Gentner³

et al. 2010

J. Neurosci.

104

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Section: ؉ Dynamics Determine the Direction Of Motor Cortical Ltp/ltmentioning

confidence: 79%

L-Type Voltage-Gated Ca²⁺Channels: A Single Molecular Switch for Long-Term Potentiation/Long-Term Depression-Like Plasticity and Activity-Dependent Metaplasticity in Humans

Wankerl¹,

Weise²,

Gentner³

et al. 2010

J. Neurosci.

104

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“…That these synapse-specific changes are related to LTP and not other states of synaptic activity is indicated by the ability of the NMDA receptor antagonist MK801 to decrease both LTP (Gilbert, 1988;Gilbert and Mack, 1990;Leung and Shen, 1993;Krug et al, 1993) and the increase in the percentage of NCAM180-immunopositive synapses. Furthermore, our results show that repeated tetanization over a longer time period did not elevate the level of potentiation reached by a strong 1-day tetanization protocol, nor did it increase the percentage of NCAM180-positive synapses, suggesting some saturation in plastic mechanisms.…”

Section: The Percentage Of Ncam180-positive Spine Synapses Changes Fomentioning

confidence: 98%

“…2(B)]. LTP was almost completely prevented by application of the noncompetitive NMDA antagonist MK801 (Gilbert, 1988;Gilbert and Mack, 1990;Leung and Shen, 1993;Krug et al, 1993) …”

Section: Electrophysiologymentioning

confidence: 98%

Increase in proportion of hippocampal spine synapses expressing neural cell adhesion molecule NCAM180 following long-term potentiation

et al. 1998

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“…Its neurophysiologic activity resembles that of ketamine, although it has a lower affinity to the receptor [9,10,11], a feature that would induce a lower rate of side effects and, unlike ketamine, it is available in oral form. DM has been used for many years as an antitussive drug [12]. The mechanism by which DM inhibits the tussive reflex is not yet known.…”

Section: Introductionmentioning

confidence: 99%

Dextromethorphan Premedication Reduces Midazolam Requirement: Objective and Subjective Parameters in Peribronchoscopy

Schwarz¹,

Greif²,

Lurie

et al. 2007

Respiration

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Background:Coughing is increased during bronchoscopy and may last for several hours after the procedure. Also prior to the procedure patients show high levels of anxiety due to fear of the pain and breathing difficulties that they might experience during the procedure. Objectives: To evaluate the antitussive, anxiolytic and sedative effect of dextromethorphan (DM) premedication on the amount of intravenous midazolam during bronchoscopic procedures. Methods: Sixty consecutive patients undergoing scheduled bronchoscopy were randomly allocated in a double-blind, placebo-controlled study. Half received 90 mg DM and half placebo. Local anesthesia with 2 ml of repeated intratracheal instillation of 1% lidocaine as needed during bronchoscopy was applied. Midazolam 1 mg (maximum of 5 mg) was administered intravenously until a satisfactory sedation was achieved. Results: Heart rate, systolic and diastolic pressure and SpO₂ were assessed before and during bronchoscopy. A visual analog score (VAS) for pain, cough, communication, cooperation, emotional state, complaints, expectoration, level of information about the procedure, feeling of unpleasantness and stress level assessed before and after the examination by the patient and the physician was used. There were no significant differences in the reported degrees of difficulty in undergoing bronchoscopic procedures. DM patients needed significantly fewer lidocaine instillations and lower midazolam dosage, achieved better analgesia, had lower emotion and complaint scores, significantly less coughing, significantly less stress, were significantly more cooperative, found that the procedure was much less unpleasant than they had expected, and produced less sputum at end of the procedure. Conclusions: DM is an effective bronchoscopic premedication in combination with midazolam and improves the overall well-being of the patients.

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Non-opioid antitussives and methadone differentially influence hippocampal long-term potentiation in freely moving rats

Cited by 23 publications

References 30 publications

L-Type Voltage-Gated Ca²⁺Channels: A Single Molecular Switch for Long-Term Potentiation/Long-Term Depression-Like Plasticity and Activity-Dependent Metaplasticity in Humans

L-Type Voltage-Gated Ca²⁺Channels: A Single Molecular Switch for Long-Term Potentiation/Long-Term Depression-Like Plasticity and Activity-Dependent Metaplasticity in Humans

Increase in proportion of hippocampal spine synapses expressing neural cell adhesion molecule NCAM180 following long-term potentiation

Dextromethorphan Premedication Reduces Midazolam Requirement: Objective and Subjective Parameters in Peribronchoscopy

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Non-opioid antitussives and methadone differentially influence hippocampal long-term potentiation in freely moving rats

Cited by 23 publications

References 30 publications

L-Type Voltage-Gated Ca2+Channels: A Single Molecular Switch for Long-Term Potentiation/Long-Term Depression-Like Plasticity and Activity-Dependent Metaplasticity in Humans

L-Type Voltage-Gated Ca2+Channels: A Single Molecular Switch for Long-Term Potentiation/Long-Term Depression-Like Plasticity and Activity-Dependent Metaplasticity in Humans

Increase in proportion of hippocampal spine synapses expressing neural cell adhesion molecule NCAM180 following long-term potentiation

Dextromethorphan Premedication Reduces Midazolam Requirement: Objective and Subjective Parameters in Peribronchoscopy

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L-Type Voltage-Gated Ca²⁺Channels: A Single Molecular Switch for Long-Term Potentiation/Long-Term Depression-Like Plasticity and Activity-Dependent Metaplasticity in Humans

L-Type Voltage-Gated Ca²⁺Channels: A Single Molecular Switch for Long-Term Potentiation/Long-Term Depression-Like Plasticity and Activity-Dependent Metaplasticity in Humans