Non-occupational exposure to asbestos is the main cause of malignant mesothelioma in women in North
                    Jutland, Denmark

Panou, Vasiliki; Vyberg, Mogens; Meristoudis, Christos; Hansen, Johnni; Bøgsted, Martin; Omland, Øyvind; Weinreich, Ulla Møller; Røe, Oluf Dimitri

doi:10.5271/sjweh.3756

Cited by 27 publications

(22 citation statements)

References 28 publications

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“…International incidence of MPM is reported to be around 1-2 per million, but in the Region of North Denmark, the crude incidence from 2010 to 2015 was 6.2/100,000 for men and 1.6/100,000 for women due to a large asbestos cement factory and shipyards that operated in the area for more than six decades [1,13]. The MM cohort of Aalborg University Hospital is one of the largest single-institution cohorts with complete clinical data regarding treatment and asbestos exposure [13].…”

Section: Introductionmentioning

confidence: 99%

Clinical prognostic factors in pleural mesothelioma: best supportive care and anti-tumor treatments in a real-life setting

et al. 2021

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Background: This study aims to investigate patient-and disease characteristics associated with survival in malignant pleural mesothelioma (MPM) patients with anti-tumor treatment or with best supportive care (BSC). Materials and methods: Consecutive MPM cases diagnosed in North Denmark Region from 1972 to 2015 were reevaluated and verified by two pathologists using modern immunohistochemical techniques. Danish registries and hospital records were used to gather patient-, asbestos exposure-, and disease information. Results: Of the 279 patients, anti-tumor treatment was administered to 184 patients (66.0%). All of those received chemotherapy alone or as part of a multimodal treatment, where pemetrexed was given to 126 (68.5%) patients. Asbestos exposure was documented in 92.5% of all patients. In the treated group, mean age was lower (66 years versus 74 years, p < 0.01), rate of occupational asbestos exposure was higher (74.5 versus 54.7%, p < 0.01), more patients had better performance score (98.4 versus 60%, p < 0.01) and stage was lower (81 versus 63.2%, p < 0.01) compared to the BSC group. Multivariate analysis showed that epithelioid subtype was the only common prognostic factor for OS in both groups. In BSC patients, good PS and female gender was associated with improved OS. Median overall survival (OS) was 17 versus 4 months (p < 0.01), and independently of the histopathological subtype, the median and 2-year survival was higher in the treated versus the BSC group (p < 0.02). Conclusions: This retrospective study showed that epithelioid subtype is the only independent positive prognostic factor of survival in treated patients with MPM. For BSC patients, the epithelioid subtype, good PS, and female gender were positive prognostic factors, while age and comorbidities were not significant. This study with long-term follow-up of treated and BSC MPM patients can contribute to the clinical stratification of patients. Further validation is appropriate to verify these findings.

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Section: Introductionmentioning

confidence: 99%

Clinical prognostic factors in pleural mesothelioma: best supportive care and anti-tumor treatments in a real-life setting

et al. 2021

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“…Both heavy and low-scale exposure to asbestos can cause MPM, as there is no safe threshold for asbestos use, and no linear dose-response relationship between MM and asbestos [12,16]. Nonetheless, some individuals are more susceptible to MPM subsequent to asbestos exposure than others, while there are also MM patients that report no exposure to asbestos or asbestos-like minerals [7,14].…”

Section: Introductionmentioning

confidence: 99%

“…The latency between exposure to asbestos and MPM diagnosis has been reported to vary between 20 and 70 years [ 11 ]. Asbestos exposure can occur occupationally for asbestos workers or non-occupationally, including domestic and environmental exposure [ 9 , 12 ]. Asbestos was prohibited in most Western countries between 1970 and 2005, except for the USA, where it is only partly banned, and Canada, where the asbestos ban was effectuated in 2018 [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review

Panou

Røe

2020

IJMS

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Malignant mesothelioma (MM) is mainly caused by air-born asbestos but genetic susceptibility is also suspected to be a risk factor. Recent studies suggest an increasing number of candidate genes that may predispose to MM besides the well-characterized BRCA1-associated protein-1 gene. The aim of this review is to summarize the most important studies on germline mutations for MM. A total of 860 publications were retrieved from Scopus, PubMed and Web of Science, of which 81 met the inclusion criteria and were consider for this review. More than 50% of the genes that are reported to predispose to MM are involved in DNA repair mechanisms, and the majority of them have a role in the homologous recombination pathway. Genetic alterations in tumor suppressor genes involved in chromatin, transcription and hypoxia regulation have also been described. Furthermore, we identified several single nucleotide polymorphisms (SNPs) that may promote MM tumorigenesis as a result of an asbestos–gene interaction, including SNPs in DNA repair, carcinogen detoxification and other genes previously associated with other malignancies. The identification of inherited mutations for MM and an understanding of the underlying pathways may allow early detection and prevention of malignancies in high-risk individuals and pave the way for targeted therapies.

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“…Nonoccupational asbestos exposure (household, domestic and neighborhood) has been identified as an important risk factor and remains the main cause of MM in women [17,20,[26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Asbestos Air Pollution: Description of a Mesothelioma Cluster Due to Residential Exposure from an Asbestos Cement Factory

Vimercati

Cavone

Delfino

et al. 2020

IJERPH

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The study describes a cluster of 71 malignant mesothelioma cases among Bari residents without asbestos exposure other than residential exposure. This small cohort, as expected, was composed of a majority of females (56.34%) with a M/F ratio of 0.8, ages ≤ 65 years old (52.11%) and the epithelioid morphological type (78.87%). Sixty-four subjects (90.14%) lived between 10 m and 1000 m from the asbestos cement factory (Fibronit), and the latency length was longer than 55 years for 25 subjects (35.21%). The adjusted risk (adjusted OR) of observing the epithelial form of mesothelioma among subjects living at small distances from Fibronit was high (OR = 1.870 (0.353–9.905)) for people living 550–1000 m from the site and for those living less than 550 m from the site (OR = 1.470 (0.262–8.248)). Additionally, the subjects with a high length of exposure showed a relevant risk of epithelioid mesothelioma both for 21–40 years of exposure (OR = 2.027 (0.521–7.890)) and more than 40 years of exposure (OR = 2.879 (0.651–12.736)). All of the estimates were high but not significant because this transitional study has a typically low power. The adjustment for latency showed the same trend. Using detailed information collected by the regional mesothelioma registry, this study provided evidence of a continuing health impact of the Fibronit asbestos cement factory in Bari on the resident population.

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Non-occupational exposure to asbestos is the main cause of malignant mesothelioma in women in North Jutland, Denmark

Cited by 27 publications

References 28 publications

Clinical prognostic factors in pleural mesothelioma: best supportive care and anti-tumor treatments in a real-life setting

Clinical prognostic factors in pleural mesothelioma: best supportive care and anti-tumor treatments in a real-life setting

Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review

Asbestos Air Pollution: Description of a Mesothelioma Cluster Due to Residential Exposure from an Asbestos Cement Factory

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