Non-obstructive hydrocephalus associated with intracranial schwannomas: hyperproteinorrhachia as an etiopathological factor?

Bloch, Jocelyne; Vernet, Olivier; Aubé, Michel; Villemure, J.-G.

doi:10.1007/s00701-002-1021-7

Cited by 46 publications

(48 citation statements)

References 11 publications

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“…1,6,13,19,20,27,29 The communicating type of hydrocephalus is more frequent (61%-87.2%), and is caused by the sloughing of protein from the tumor secondary to increased vascular endothelial permeability, the development of meningeal adhesions, arachnoiditis, or seeding of tumor cells. 4,8,10,11,16 The decreased reserve capacity for CSF absorption due to aging might explain the higher rate of communicating hydrocephalus in elderly patients. 29 Obstructive hydrocephalus is observed in 12.8%-39% of all patients.…”

Section: Discussionmentioning

confidence: 99%

Hydrocephalus associated with vestibular schwannomas: management options and factors predicting the outcome

Gerganov

Pirayesh

Nouri

et al. 2011

JNS

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Object The current, generally accepted optimal management for hydrocephalus related to vestibular schwannomas (VSs) is primary tumor removal, with further treatment reserved only for patients who remain symptomatic. Previous studies have shown, however, that this management can lead to an increase in surgery-related complications. In this study, the authors evaluated their experience with the treatment of such patients, with the aim of identifying the following: 1) the parameters correlating to the need for specific hydrocephalus treatment following VS surgery; and 2) patients at risk for developing hydrocephalus-related complications. Methods This was a retrospective study of a 400-patient series. The complication rates and outcomes following primary hydrocephalus treatment versus primary VS removal were compared. Patients undergoing primary tumor removal were further subdivided on the basis of the need for subsequent hydrocephalus treatment. The 3 categories of parameters tested for correlation with the need for such subsequent treatment as well as with heightened risk for developing complications were patient-, tumor-, and hydrocephalus-related. Results Of the entire series, 53 patients presented with hydrocephalus. Forty-eight of 53 patients underwent primary VS surgery, of whom 42 (87.5%) did not require additional hydrocephalus treatment. Of the 6 patients who did require additional hydrocephalus treatment, only 3 ultimately required a VP shunt. Factors correlating to the need of hydrocephalus treatment after VS removal were large tumor size, irregular tumor surface, and severe preoperative hydrocephalus. Patients with a longer symptom duration prior to surgery, those with polycyclic tumors, or with inhomogeneous VS, were at heightened risk for the development of CSF leaks. The general and functional outcome of surgery showed no correlation to the presence of preoperative hydrocephalus. Conclusions Primary tumor removal is the optimum management of disease in patients with VS with associated hydrocephalus; it leads to resolution of the hydrocephalus in the majority of cases, and the outcome is similar to that of patients without hydrocephalus. Certain factors may aid in identifying patients at risk for developing persistent hydrocephalus as well as those at risk for CSF leaks.

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Section: Discussionmentioning

confidence: 99%

Hydrocephalus associated with vestibular schwannomas: management options and factors predicting the outcome

Gerganov

Pirayesh

Nouri

et al. 2011

JNS

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“…1) The diagnosis of NPH has become increasingly sophisticated since the first descriptions. 4) NPH and other diseases affect cognitive function through frontal lobe dysfunction which impairs attention, memory, and language understanding.…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Constructional Skill Testing in Patients With Secondary Normal Pressure Hydrocephalus -Two Case Reports-

Takeuchi

Hayashi

Takaiwa

et al. 2007

Neurol. Med. Chir.(Tokyo)

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Cognitive functions are frequently impaired in patients with normal pressure hydrocephalus (NPH). Two patients with NPH initially had dysfunctional constructional skill but exhibited improvements after shunt surgery. Dysfunction of constructional skill should be added to the important clinical features of NPH. The geometric test can be used as a practical tool for evaluation of parietal lobe function in patients with NPH.

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“…Radiosurgery may aggravate cerebrospinal fluid (CSF) malabsorption by causing radiation necrosis, with elevated CSF protein levels. 3,6 Additionally, it is unclear whether further surgical intervention is necessary for those patients who develop communicating HCP. The aim of this retrospective cohort study is to determine the incidence of communicating HCP developing after two treatment modalities for VS.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 By contrast, since its introduction in 1969, stereotactic radiosurgery has become widely advocated as a minimally invasive treatment of VS. 3 However, despite the associated low morbidity and acceptable efficacy of GKS, some factors during follow-up need to be considered. Some investigators have suggested that communicating hydrocephalus (HCP) may develop after GKS for of VS. [4][5][6] To date, the mechanism by which communicating HCP occurs is unknown. Radiosurgery may aggravate cerebrospinal fluid (CSF) malabsorption by causing radiation necrosis, with elevated CSF protein levels.…”

Section: Introductionmentioning

confidence: 99%

Communicating hydrocephalus associated with surgery or radiosurgery for vestibular schwannoma

Jeon

Kong

Nam

et al. 2010

Journal of Clinical Neuroscience

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Non-obstructive hydrocephalus associated with intracranial schwannomas: hyperproteinorrhachia as an etiopathological factor?

Abstract: The constant finding of hyperproteinorrhachia in all these patients suggests that a high CSF protein content may be the underlying cause of hydrocephalus through a speculative mechanism of decreased CSF resorption.

Cited by 46 publications

References 11 publications

Hydrocephalus associated with vestibular schwannomas: management options and factors predicting the outcome

Hydrocephalus associated with vestibular schwannomas: management options and factors predicting the outcome

Clinical Value of Constructional Skill Testing in Patients With Secondary Normal Pressure Hydrocephalus -Two Case Reports-

Communicating hydrocephalus associated with surgery or radiosurgery for vestibular schwannoma

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