Non-Obstructive Coronary Artery Disease in Women: Current Evidence and Future Directions

Smith, Leanna; Salifu, Moro O.; McFarlane, Isabel M.

doi:10.15344/2456-8007/2020/152

Cited by 6 publications

(6 citation statements)

References 58 publications

(36 reference statements)

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“…On the other hand, potential mechanisms of CAD could be worsened by COVID-19 infection including plaque disruption, dissection, thromboembolism, vasomotor and microvascular dysfunction, and supply/demand mismatch [ 14 , 15 , 24 , 26 ]. Interestingly, previous studies show that non-obstructive CAD is more commonly associated with women than men [ [28] , [29] , [30] ]. Consequently, the vast majority of people still present with MI and obstructive etiologies; simultaneously, the number of non-obstructive causes due to COVID-19 is increasing.…”

Section: Discussionmentioning

confidence: 99%

Symptomatology, prognosis and clinical findings of STEMI as a ramification of COVID-19: A systematic review and proportion meta-analysis

Jaiswal

Almas

Ang

et al. 2022

Annals of Medicine &Amp; Surgery

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Section: Discussionmentioning

confidence: 99%

Symptomatology, prognosis and clinical findings of STEMI as a ramification of COVID-19: A systematic review and proportion meta-analysis

Jaiswal

Almas

Ang

et al. 2022

Annals of Medicine &Amp; Surgery

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“…One possible reason is that the symptoms of CHD in females are atypical, which delays the time to medical contact for female patients. A recent study showed that female patients are more likely to be complicated with coronary microvascular dysfunction, which may also be a reason for the higher risk of death [31].…”

Section: Discussionmentioning

confidence: 99%

Development of a novel tool: a nomogram for predicting in-hospital mortality of patients in intensive care unit after percutaneous coronary intervention

et al. 2023

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Backgrounds Increased risk of in-hospital mortality is critical to guide medical decisions and it played a central role in intensive care unit (ICU) with high risk of in-hospital mortality after primary percutaneous coronary intervention (PCI). At present，most predicting tools for in-hospital mortality after PCI were based on the results of coronary angiography, echocardiography, and laboratory results which are difficult to obtain at admission. The difficulty of using these tools limit their clinical application. This study aimed to develop a clinical prognostic nomogram to predict the in-hospital mortality of patients in ICU after PCI. Methods We extracted data from a public database named the Medical Information Mart for Intensive Care (MIMIC III). Adult patients with coronary artery stent insertion were included. They were divided into two groups according to the primary outcome (death in hospital or survive). All patients were randomly divided into training set and validation set randomly at a ratio of 6:4. Least absolute shrinkage and selection operator (LASSO) regression was performed in the training set to select optimal variables to predict the in-hospital mortality of patients in ICU after PCI. The multivariate logistical analysis was performed to develop a nomogram. Finally, the predictive efficiency of the nomogram was assessed by area under the receiver operating characteristic curve (AUROC)，integrated discrimination improvement (IDI), and net reclassification improvement (NRI), and clinical net benefit was assessed by Decision curve analysis (DCA). Results A total of 2160 patients were recruited in this study. By using LASSO, 17 variables were finally included. We used multivariate logistic regression to construct a prediction model which was presented in the form of a nomogram. The calibration plot of the nomogram revealed good fit in the training set and validation set. Compared with the sequential organ failure assessment (SOFA) and scale for the assessment of positive symptoms II (SAPS II) scores, the nomogram exhibited better AUROC of 0.907 (95% confidence interval [CI] was 0.880-0.933, p < 0.001) and 0.901 (95% CI was 0.865-0.936, P < 0.001) in the training set and validation set, respectively. In addition, DCA of the nomogram showed that it could achieve good net benefit in the clinic. Conclusions A new nomogram was constructed, and it presented excellent performance in predicting in-hospital mortality of patients in ICU after PCI.

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“…Angina is frequently misdiagnosed in women, particularly in absence of coronary arteries lesions [ 245 ]. Female sex was associated, instead, with the prescription of short- and long-acting nitrates [ 47 ].…”

Section: Treatment Of Cardiovascular Diseases In Both Sexes: Differen...mentioning

confidence: 99%

Update on Management of Cardiovascular Diseases in Women

Lucà¹,

Abrignani

Parrini

et al. 2022

JCM

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Cardiovascular diseases (CVD) have a lower prevalence in women than men; although, a higher mortality rate and a poorer prognosis are more common in women. However, there is a misperception of CVD female risk since women have commonly been considered more protected so that the real threat is vastly underestimated. Consequently, female patients are more likely to be treated less aggressively, and a lower rate of diagnostic and interventional procedures is performed in women than in men. In addition, there are substantial sex differences in CVD, so different strategies are needed. This review aims to evaluate the main gender-specific approaches in CVD.

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Non-Obstructive Coronary Artery Disease in Women: Current Evidence and Future Directions

Cited by 6 publications

References 58 publications

Symptomatology, prognosis and clinical findings of STEMI as a ramification of COVID-19: A systematic review and proportion meta-analysis

Symptomatology, prognosis and clinical findings of STEMI as a ramification of COVID-19: A systematic review and proportion meta-analysis

Development of a novel tool: a nomogram for predicting in-hospital mortality of patients in intensive care unit after percutaneous coronary intervention

Update on Management of Cardiovascular Diseases in Women

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