Non-Neuronal Transmitter Systems in Bacteria, Non-Nervous Eukaryotes, and Invertebrate Embryos

Abstract

In 1921, Otto Loewi published his report that ushered in the era of chemical transmission of biological signals. January 2021 marked the 90th anniversary of the birth of Professor Gennady A. Buznikov, who was the first to study the functions of transmitters in embryogenesis. A year earlier it was 60 years since his first publication in this field. These data are a venerable occasion for a review of current knowledge on the mechanisms related to classical transmitters such as 5-hydroxytryptamine, acetylcholine, catecholamines, etc., in animals lacking neural elements and prenervous invertebrate embryos.

Uptake and Metabolization of Serotonin by Granulosa Cells Form a Functional Barrier in the Mouse Ovary

“…Almost all 5-HT is distributed in the periphery, mainly in the gut and blood platelets [ 2 ], and is involved in the regulation of a number of physiological processes [ 1 ]. 5-HT also plays an important role in the female reproductive system, as its conserved function is to modulate egg maturation, ovulation, and early embryonic development [ 3 , 4 , 5 ]. The importance of studying 5-HT in the ovaries is related to the widespread use of neurochemical drugs, such as antidepressants.…”