Non-Neoplastic Findings

Young, Nancy A.; Bibbo, Marluce; Buckner, Sally-Beth; Colgan, Terence J.; Prey, Marianne U.

doi:10.1007/978-1-4612-2042-8_2

Cited by 5 publications

(1 citation statement)

References 18 publications

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“…In light of the more recent TBS 2001 criteria 3 and availability of reflex hr-HPV testing, our goal was to investigate the relationship between Pap tests with di- agnoses of both ASCUS and Candida and the presence of hr-HPV. Evaluating for the presence of hr-HPV is a more objective measure of preneoplastic potential due to the known role of hr-HPV types in cervical dysplasia and neoplasia.…”

Section: Discussionmentioning

confidence: 99%

High Risk Human Papillomavirus DNA Detection in Pap Tests with Both Atypical Squamous Cells of Undetermined Significance and Candida

Hall

Kendall²

2009

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

High Risk Human Papillomavirus DNA Detection in Pap Tests with Both Atypical Squamous Cells of Undetermined Significance and Candida

Hall

Kendall²

2009

Acta Cytologica

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Differential diagnosis of well‐differentiated squamous cell carcinoma from non‐neoplastic oral mucosal lesions: New cytopathologic evaluation method dependent on keratinization‐related parameters but not nuclear atypism

Hara

Misawa

Ishii

et al. 2017

Diagnostic Cytopathology

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Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan

et al. 2021

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Background As the population ages in developed countries, the number of Pap smears for cervical cancer screening of older women is increasing. There is concern that cervical atrophy may cause misinterpretation of results for this segment of the population. The present study evaluated the accuracy of screening for high-grade intraepithelial lesions (HSILs) in women younger or older than 50 years, to determine whether aging affects cytological interpretation. Methods Patients with HSIL cytology (N = 1565) were dichotomized into those aged 20–49 years or aged ≥ 50 years. Association between histology results and age was examined. Pearson’s chi-squared test and Cochran-Armitage trend test were used for statistical analysis. Results The positive predictive value (PPV) for cervical intraepithelial neoplasia (CIN)2 and worse was 65.2% (62/95) in older women but 87.3% (482/552) in younger women (p < 0.001). Older patients had a significantly lower PPV (p = 1.69 × 10–8). Separately analyzing chronic cervicitis, CIN1 and overt cancer grouped together, compared with another group composed of CIN2 and CIN3, we found that the PPV for CIN2 and CIN3 was lower in older than in younger women [44.2% (42/95)-vs-82.4% (455/552), p < 0.001], respectively. Conclusions HSILs are associated with a wide range of disease categories as age increases, and the accuracy of HSIL interpretation is lower in older women.

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Non-Neoplastic Findings

Cited by 5 publications

References 18 publications

High Risk Human Papillomavirus DNA Detection in Pap Tests with Both Atypical Squamous Cells of Undetermined Significance and Candida

High Risk Human Papillomavirus DNA Detection in Pap Tests with Both Atypical Squamous Cells of Undetermined Significance and Candida

Differential diagnosis of well‐differentiated squamous cell carcinoma from non‐neoplastic oral mucosal lesions: New cytopathologic evaluation method dependent on keratinization‐related parameters but not nuclear atypism

Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan

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