Non-motor symptoms in patients with amyotrophic lateral sclerosis: current state and future directions
Bogdan Bjelica,
Maj-Britt Bartels,
Jasper Hesebeck-Brinckmann
et al.
Abstract:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of both upper and lower motor neurons. A defining histopathological feature in approximately 97% of all ALS cases is the accumulation of phosphorylated trans-activation response (TAR) DNA-binding protein 43 protein (pTDP-43) aggregates in the cytoplasm of neurons and glial cells within the central nervous system. Traditionally, it was believed that the accumulation of TDP-43 aggregates and sub… Show more
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