Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort

Abstract

The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.

Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability

“…First, it is important to note the specific distribution of ICBs in our sample, which is quite similar to that of Jesus et al. (2020) ( Jesus et al., 2020 ).…”

“…First, it is important to note the specific distribution of ICBs in our sample, which is quite similar to that of Jesus et al. (2020) ( Jesus et al., 2020 ). In contrast to some studies (see ( Grall-Bronnec et al., 2018 ) for a review), binge eating was the most frequently observed ICB.…”

Impulse control disorders and related behaviors in Parkinson's disease: risk factors, clinical and genetic aspects, and management

“…A younger age, younger age at PD onset and male sex have been associated with ICDRBs [36,45,46,[58][59][60]. Differences between sexes depending on ICDRBs subtypes were observed, with women developing more compulsive buying and eating disorders and men developing more pathological gambling and hypersexuality disorders [61,62], although the same differences have been reported in the general population [63].…”

“…PD patients with ICDs show a higher level of neuroticism and lower levels of agreeableness and conscientiousness [58], particularly among PD patients with pathological gambling [66] or hypersexuality [10]. Such patients are also reported to have ineffective coping skills [67], premorbid personality (novelty seeking and harm avoidance) [60], and anxiety [68].…”

Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics

“…In other words, the associations between pain and other nonmotor symptoms may reflect shared protective and risk factors, in addition to possible common pathophysiological mechanisms. Supporting this hypothesis is the reported association between poor quality of sleep and both central parkinsonian pain [ 8 ] and ICDs [ 36 ] in PD. We observed in the present study that patients with central parkinsonian pain had more preserved cognition.…”