Non-membrane enclosed intramitochondrial dense bodies

Minick, O. T.; Kent, Geoffrey; Orfei, Emilio; Volini, Frederick I.

doi:10.1016/0014-4800(65)90006-7

Cited by 14 publications

(1 citation statement)

References 8 publications

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“…11, 13) that are ominous as portents of cell death. 24 The inhomogeneous distribution of mitochondria (Fig. 7), and the cell-to-cell differences (Fig.…”

Section: Discussionmentioning

confidence: 98%

An array of mitochondrial alterations in the hepatocytes of long-evans cinnamon rats

et al. 1995

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In an attempt to identify the cellular targets of copper toxicity, we studied the ultrastructure of hepatocytes in the livers of 23 Long-Evans Cinnamon (LEC) rats ranging in age from 10 to 89 weeks. The hepatic copper concentration ranged from 325 to 2,126 (mean, 930) micrograms/g dry weight. Thirteen rats displayed varying degrees of jaundice at the time of killing. Numerous nuclei were indented by cytoplasmic invaginations. Conspicuous abnormalities were displayed by mitochondria. These included marked pleomorphism; increased or diminished matrical density; rearrangement, elongation, dilatation, stacking, or disappearance of cristae; absence of matrical granules; presence of matrical inclusions of flocculent electron-dense deposits; and degenerative changes. The severity of the ultrastructural changes did not correlate with the hepatic copper concentration but did correlate with the degree of the icterus displayed by the rats. Certain mitochondrial changes resembled those encountered in the hepatocytes of patients with Wilson's disease, confirming that these organelles are important targets of copper toxicity.

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“…11, 13) that are ominous as portents of cell death. 24 The inhomogeneous distribution of mitochondria (Fig. 7), and the cell-to-cell differences (Fig.…”

Section: Discussionmentioning

confidence: 98%

An array of mitochondrial alterations in the hepatocytes of long-evans cinnamon rats

et al. 1995

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The occurrence of tubular intramitochondrial inclusions in the post‐mortem zona fasciculata of the rat adrenal

Dietert

1969

Anat. Rec.

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Adult male albino rats are decapitated and the mitochondria in one adrenal gland are examined at increasing post-mortem time intervals in the electron microscope. The contralateral adrenal gland is excised rapidly, immersed in aldehyde fixative, diced, and used as the control. As early as 15 minutes post-mortem, tightly packed sheaves of tubules (each tubule measuring 140 A in outside diameter) appear as inclusions in the matrix of mitochondria within the zona fasciculata. These inclusions occur in increasing numbers of mitochondria during the first hour postmortem, until 10-25% of the mitochondria examined contain at least one sheaf of tubules. Observations at two and three hours post-mortem reveal no significant increase in inclusioncontaining mitochondria. At these late time intervals additional postmortem alterations are evident: (1) a decrease in mitochondrial matrix density; ( 2 ) swelling of mitochondria1 cristae; and (3) vesiculation of the smooth reticulum.Kjaerheim ('67), Wheatley (%a), and MagalhLes and MagalhPes ('68) have described tubular inclusions in the matrix of "normal" rat adrenal mitochondria which are identical to the post-mortem inclusions described in this study. The presence of such inclusions in control mitochondria has been observed by the author on one occasion: within a degenerate mitochondrion enclosed inside a cytoplasmic membrane-limited vacuole. The possible significance of this post-mortem mitochondrial alteration in the rat adrenal cortex is discussed.

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Mitochondrial Changes in Axonal Dystrophy Produced by Vitamin E Deficiency

Schochet

1971

Symposium on Pathology of Axons and Axonal Flow

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Non-membrane enclosed intramitochondrial dense bodies

Cited by 14 publications

References 8 publications

An array of mitochondrial alterations in the hepatocytes of long-evans cinnamon rats

An array of mitochondrial alterations in the hepatocytes of long-evans cinnamon rats

The occurrence of tubular intramitochondrial inclusions in the post‐mortem zona fasciculata of the rat adrenal

Mitochondrial Changes in Axonal Dystrophy Produced by Vitamin E Deficiency

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