Non-Melanosomal Regulatory Factors in Melanogenesis.

Shibata, Takakazu; Prota, Giuseppe; Mishima, Yutaka

doi:10.1111/1523-1747.ep12470147

Cited by 23 publications

(24 citation statements)

References 20 publications

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“…CRH, ACTH, MSH and β-endorphins clearly play a melanogenic function Kauser et al 2004;2005;Hirobe 2005;Paus 2011), while serotonin (O'Malley 1960; Slominski et al 2004), dopamine (Slominski et al 2004), adrenaline and noradrenaline (O'Malley 1960) exert an inhibiting effect on melanogenesis. Regarding corticosteroids, some authors are of the opinion that they stimulate the biosynthesis of melanin (Shibata et al 1993), while others have demonstrated their depigmentation effects (Arnold et al 1975).…”

Section: Lerner Cited In Slominski 2009)mentioning

confidence: 99%

Effects of psychological stress on skin and hair pigmentation in Polish adolescents

Sitek

Żądzińska

Rosset

2012

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The effects of psychological stress, gender and age on hair and skin pigmentation levels were evaluated in the reported study. The material included Polish high-school and university students aged 18-22 (in the age range 17.50-22.49). All subjects who had sunbathed or used tanning beds or lamps, skin tanning agents, tanning extenders and/or medical agents affecting skin pigmentation during the 60 days preceding the beginning of the study were excluded. The use of hormonal contraceptives within a month prior to the study was also an excluding factor. Stress levels were evaluated by the Perceived Stress Scale (PSS-10) in the Polish adaptation, while hair and skin pigmentation levels were assessed with a dermaspectrometer (Cortex Technology®, Denmark, 2007). The study was carried out with the exclusion of the summer period. Skin pigmentation was evaluated in 395 subjects (264 women and 131 men). Hair pigmentation was analyzed in a smaller group of 351 subjects (223 women and 128 men), as some had had their hair dyed within 12 months prior to the study while in some others the hair was too short to be correctly measured. Regardless of their age, the studied women felt much more stress related to their life situation and were characterized by stronger skin pigmentation than the examined men. No sex differences were identified with regard to hair pigmentation. In the studied period of ontogenesis (18-22 years of age), hair pigmentation levels increased with age, while skin melanization remained stable. Disregarding the effects of age and sex, the level of perceived stress was negatively correlated with skin pigmentation levels; no such relationship was found for hair melanization.

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Section: Lerner Cited In Slominski 2009)mentioning

confidence: 99%

Effects of psychological stress on skin and hair pigmentation in Polish adolescents

Sitek

Żądzińska

Rosset

2012

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“…A third enzymatic role has been proposed for tyrosinase: the oxidation of 5,6-dihydroxyindole to 5,6-dihydroxyquinone [22,24]. However, it has also been proposed that this oxidation is performed through a peroxidase [25]. Tyrosinase preparations are enzymatically active at a pH range of 5-8, but in vivo the enzyme might encounter even lower values due to the acidic intramelanosomal pH [26].…”

Section: Introductionmentioning

confidence: 99%

Tyrosinase and related proteins in mammalian pigmentation

Marmol

Beermann²

1996

FEBS Letters

408

260

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Tyrosinase is the key enzyme in pigment synthesis, initiating a cascade of reactions which convert the amino acid tyrosine to the melanin biopolymer. Two other tyrosinase-related proteins (TRP) are known, TRP-1 (probably DHICAoxidase) and TRP-2 (DOPAchrome tautomerase). These proteins show about 40% homology, and recent results have indicated that the genes might be derived from a common ancestor. We will discuss recent findings on genomic organization, and on the proteins and their presumed function, which is important for eumelanin synthesis in mouse and man.

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“…Some of these steps include the oxidation of DOPA [16, 17], the oxidative polymerization of indolic melanin monomers to eumelanin [18], and the polymerization of benzothiazine type intermediates to pheomelanin [19, 20]. The inhibition of peroxidase by MMI could interfere with melanin synthesis at different steps, explaining its depigmenting action on the skin.…”

Section: Discussionmentioning

confidence: 99%

Topical Methimazole as a New Treatment for Postinflammatory Hyperpigmentation: Report of the First Case

Kasraee¹,

Handjani²,

Parhizgar³

et al. 2005

Dermatology

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We have previously shown that the peroxidase inhibitor methimazole (1-methyl-2-mercapto imidazole; MMI) is a noncytotoxic inhibitor of melanin production in cultured B16 melanocytes. It was further demonstrated that the topical application of 5% MMI on brown guinea pig skin for 6 weeks causes a significant reduction in the amount of epidermal melanin, resulting in visually recognizable cutaneous depigmentation. Herein, we report a 27-year-old male with postinflammatory hyperpigmentation (due to acid burn), successfully treated with topical MMI as a new skin depigmenting agent. Topical 5% MMI caused a moderate to marked improvement of the hyperpigmented lesions within 6 weeks of once-daily application. Topical MMI was well tolerated by the patient and did not affect the level of serum thyroid hormones (free thyroxin, free triiodothyronine and the thyroid-stimulating hormone). Unlike most known depigmenting agents, such as hydroquinone and kojic acid, MMI is a noncytotoxic, nonmutagenic compound, and it is possible that MMI could serve as a novel agent for the treatment of hyperpigmentary disorders in human.

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Non-Melanosomal Regulatory Factors in Melanogenesis.

Cited by 23 publications

References 20 publications

Effects of psychological stress on skin and hair pigmentation in Polish adolescents

Effects of psychological stress on skin and hair pigmentation in Polish adolescents

Tyrosinase and related proteins in mammalian pigmentation

Topical Methimazole as a New Treatment for Postinflammatory Hyperpigmentation: Report of the First Case

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