Non-melanoma skin cancer risk in the Queensland renal transplant population

Ramsay, Helen M.; Fryer, Anthony A.; Hawley, Carmel M.; Smith, Andrew G.; Nicol, David; Harden, Paul

doi:10.1046/j.1365-2133.2002.04976.x

Cited by 249 publications

(246 citation statements)

References 16 publications

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“…However, there is a high occurrence of certain cancers in long-term survivors of these patients (33)(34)(35). For example, 20 years after transplant, about 60 -90% of the patients who have taken azathioprine as an immunosuppressant develop squamous cell carcinoma (36). The oxidation of S G to SO3H G and the high mutagenic potential of the latter as revealed by the present in vivo mutagenesis study may account for the development of cancers in those patients.…”

Section: Discussionmentioning

confidence: 87%

Mutagenic and Cytotoxic Properties of 6-Thioguanine, S-Methylthioguanine, and Guanine-S6-sulfonic Acid

Yuan

Wang

2008

Journal of Biological Chemistry

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Thiopurine drugs, including 6-thioguanine ( S G), 6-mercaptopurine, and azathioprine, are widely employed anticancer agents and immunosuppressants. The formation of S G nucleotides from the thiopurine prodrugs and their subsequent incorporation into nucleic acids are important for the drugs to exert their cytotoxic effects.S G in DNA can be methylated by S-adenosyl-L-methionine to give S 6 -methylthioguanine (S 6 mG) and oxidized by UVA light to render guanine-S 6 -sulfonic acid ( SO3H G). Here, we constructed single-stranded M13 shuttle vectors carrying a S G, S 6 mG, or SO3H G at a unique site and allowed the vectors to propagate in wild-type and bypass polymerasedeficient Escherichia coli cells. Analysis of the replication products by using the competitive replication and adduct bypass and a slightly modified restriction enzyme digestion and post-labeling assays revealed that, although none of the three thionucleosides considerably blocked DNA replication in all transfected E. coli cells, both S 6 mG and SO3H G were highly mutagenic, which resulted in G3 A mutation at frequencies of 94 and 77%, respectively, in wild-type E. coli cells. Deficiency in bypass polymerases does not result in alteration of mutation frequencies of these two lesions. In contrast to what was found from previous steady-state kinetic analysis, our data demonstrated that 6-thioguanine is mutagenic, with G3 A transition occurring at a frequency of ϳ10%. The mutagenic properties of 6-thioguanine and its derivatives revealed in the present study offered important knowledge about the biological implications of these thionucleosides.

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Section: Discussionmentioning

confidence: 87%

Mutagenic and Cytotoxic Properties of 6-Thioguanine, S-Methylthioguanine, and Guanine-S6-sulfonic Acid

Yuan

Wang

2008

Journal of Biological Chemistry

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“…Previous studies demonstrate an association between solid organ transplantation and an increased risk for solid cancers, particularly SCCs. [7][8][9]28,29 Conventional BMT also appears to increase the risk of developing skin cancer, particularly squamous cell of the skin and buccal cavity. [10][11][12][13][14] Curtis et al 14 compared clinical characteristics of 183 patients who developed secondary cancers (58 SCCs, 125 non-SCCs) and 501 matched control patients within a Table 3 Chronic GVHD in six patients who developed skin cancer after NMAT 11 reported a cohort of 56 patients that were followed for a minimum of 40 months following conventional BMT for aplastic anemia and leukemias; three patients developed secondary malignancy of the skin or oral mucosa, including two SCCs and one melanoma.…”

Section: Discussionmentioning

confidence: 99%

“…5 Subsequent studies confirmed the association between solid organ transplantation/immunosuppression and the development of SCC, BCC and other skin neoplasms. [6][7][8] The relative risk for such tumors in solid organ recipients is estimated to be 92 and 108 for women and men, respectively. 9 Bone marrow transplantation is associated with an increased incidence of secondary malignancies; conventional, myeloablated transplant recipients are at increased risk for malignant melanoma and SCC of the buccal cavity and skin.…”

Section: Introductionmentioning

confidence: 99%

Skin cancer after nonmyeloablative hematopoietic cell transplantation

Cavalier

Shmalo

et al. 2006

Bone Marrow Transplant

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“…The literature suggests that the posttransplantation skin cancer incidence varies geographically, occurring with increased frequency in geographical latitudes associated with high ambient sun exposure [2][3][4][5][6][7][8][9][10] . The highest figures have been observed in the transplant population studies in Australia and New Zealand 3,4 .…”

Section: Discussionmentioning

confidence: 99%

Skin Cancer Incidence in Renal Transplant Recipients - A Single Center Study

Kalinová¹,

Májek²,

Stehlík³

et al. 2010

BIOMED PAP

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Aims.To provide the first single-center study of a Czech renal transplant program that compares skin cancer risk estimates to the general population.Methods. We studied a total of 603 patients undergoing renal transplantation at the University Hospital Olomouc Transplant Center between January 1984 and December 2009. The mean time of follow-up was 5.5 years. Three patients were excluded for skin cancer diagnosis before transplant. The cohort was linked with the National Cancer Registry of the Czech Republic. For non-melanoma skin cancer (NMSC), the observed number of cancers were compared to the expected numbers of NMSC based on national cancer incidence rates stratified by age. The standartized incidence ratio (SIR) was calculated as observed-to-expected ratios.Results. We found a total of 127 cases of skin cancers in 55 patients. 52/55 (94.5%) were patients with non-melanoma skin cancers, 2/55 (3.6%) patients had malignant melanoma, and we uncovered one case of merkel cell carcinoma of the skin (1.8%). There were no cases of Kaposi's sarcoma, cutaneous lymphoma or malignant fibrous histiocytoma. For NMSC, the overall SIR was 7.39 (95% confidence interval 5.52-9.70). Thus, skin cancer was the most common malignant condition, representing 64.1% of all malignant tumours detected in study population.Conclusion. We confirmed that skin cancer is a major complication in renal transplant recipients. Therefore it is important to increase the intensity of surveillence for these lesions in transplant patients.

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Non-melanoma skin cancer risk in the Queensland renal transplant population

Abstract: NMSC is a greater clinical problem in renal transplant recipients living in subtropical Queensland, Australia, than is shown by currently available registry data. This has implications for the development of prevention and surveillance strategies.

Cited by 249 publications

References 16 publications

Mutagenic and Cytotoxic Properties of 6-Thioguanine, S-Methylthioguanine, and Guanine-S6-sulfonic Acid

Mutagenic and Cytotoxic Properties of 6-Thioguanine, S-Methylthioguanine, and Guanine-S6-sulfonic Acid

Skin cancer after nonmyeloablative hematopoietic cell transplantation

Skin Cancer Incidence in Renal Transplant Recipients - A Single Center Study

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