Non-local muscle fatigue: effects and possible mechanisms

Halperin, Israel; Chapman, Dale W.; Behm, David G.

doi:10.1007/s00421-015-3249-y

Cited by 84 publications

(106 citation statements)

References 101 publications

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“…Although divergent findings exist (Halperin et al . ), this observation appears to agree with the idea that cross‐over fatigue (measured via reduced force during a single MVC or increased central fatigue) does not occur in the lower limb muscles (Regueme et al . ; Paillard et al .…”

Section: Discussionsupporting

confidence: 90%

“…2C and D). Although divergent findings exist (Halperin et al 2015), this observation appears to agree with the idea that cross-over fatigue (measured via reduced force during a single MVC or increased central fatigue) does not occur in the lower limb muscles (Regueme et al 2007;Paillard et al 2010;Amann et al 2013;Aboodarda et al 2015;Kennedy et al 2015;Prieske et al 2017). Given that no changes were observed for measures of central fatigue (VA PNS and VA TMS ) following LL condition ( Fig.…”

Section: Neuromuscular Performancesupporting

confidence: 82%

“…A similar effect on exercise performance was found in the lower limb muscles after prior fatiguing arm cranking exercises (Bangsbo et al 1996;Nordsborg et al 2003;Johnson et al 2015). The reduced exercise capacity and accelerated neuromuscular fatigue within the tested muscle groups have been attributed to central inhibitory factors mediated by afferent feedback from pre-fatigued muscles (Kennedy et al 2013;Sidhu et al 2014;Halperin et al 2015;Hureau et al 2018). However, there is no empirical evidence to elaborate whether this 'spillover' of central inhibitory effects during dynamic locomotor exercise would exacerbate central fatigue in the contralateral/tested muscle groups.…”

Section: Introductionmentioning

confidence: 62%

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Effects of pre‐induced fatigue vs. concurrent pain on exercise tolerance, neuromuscular performance and corticospinal responses of locomotor muscles

Aboodarda

Iannetta

Emami

et al. 2020

The Journal of Physiology

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Key points Fatigue and muscle pain induced in a remote muscle group has been shown to alter neuromuscular performance in exercising muscles. Inhibitory neural feedback associated with activation of mechano‐ and metabo‐sensitive muscle afferents has been implicated in this phenomenon. The present study aimed to quantify and compare the effects of pre‐induced fatigue and concurrent rising pain (evoked by muscle ischaemia) on the contralateral leg exercise capacity, neuromuscular performance, and corticomotor excitability and inhibition of knee extensor muscles. Pre‐induced fatigue in one leg had a greater detrimental effect than the concurrent rising pain on the contralateral limb cycling capacity. Furthermore, pre‐induced fatigue, but not concurrent rising pain, reduced corticospinal inhibition recorded from tested contralateral muscles. Regardless of the origin or mechanisms modulating sensory afferents during single‐leg cycling exercise (i.e. pre‐induced fatigue vs. concurrent rising pain), the limit of exercise tolerance remained the same and exercise was terminated upon achievement of a sensory tolerance limit. Abstract Individuals often need to maintain voluntary contractions during high intensity exercise in the presence of fatigue and pain. This investigation examined the effects of pre‐induced fatigue and concurrent rising pain (evoked by muscle ischaemia) in one leg on motor fatigability and corticospinal excitability/inhibition of the contralateral limb. Twelve healthy males undertook four experimental protocols including unilateral cycling to task failure at 80% of peak power output with: (i) the right‐leg (RL); (ii) the left‐leg (LL); (iii) RL immediately preceded by LL protocol (FAT‐RL); and (iv) RL when blood flow was occluded in the contralateral (left) leg (PAIN‐RL). Participants performed maximal and submaximal 5 s right‐leg knee extensions during which transcranial magnetic and femoral nerve electrical stimuli were delivered to elicit motor‐evoked and compound muscle action potentials, respectively. The pre‐induced fatigue reduced the right leg cycling time‐to‐task failure (mean ± SD; 332 ± 137 s) to a greater extent than concurrent pain (460 ± 158 s), compared to RL (580 ± 226 s) (P < 0.001). The maximum voluntary contraction force declined less following FAT‐RL (P < 0.019) and PAIN‐RL (P < 0.032) compared to RL. Voluntary activation declined and the corticospinal excitability recorded from knee extensors increased similarly after the three conditions (P < 0.05). However, the pre‐induced fatigue, but not concurrent pain, reduced corticospinal inhibition compared to RL (P < 0.05). These findings suggest that regardless of the origin and/or mechanisms modulating sensory afferent feedback during single‐leg cycling (e.g. pre‐induced fatigue vs. concurrent rising pain), the limit of exercise tolerance remains the same, suggesting that exercise will be terminated upon achievement of sensory tolerance limit.

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Section: Discussionsupporting

confidence: 90%

Section: Neuromuscular Performancesupporting

confidence: 82%

Section: Introductionmentioning

confidence: 62%

See 1 more Smart Citation

Effects of pre‐induced fatigue vs. concurrent pain on exercise tolerance, neuromuscular performance and corticospinal responses of locomotor muscles

Aboodarda

Iannetta

Emami

et al. 2020

The Journal of Physiology

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“…It is also feasible that training to MMF may impart greater adaptations in a contralateral limb due to potentially greater stimulus of centrally mediated neural factors through non local muscular fatigue (NLMF;Halperin et al, 2015). Whilst it is not within the scope of this article to provide extensive discussion, in brief; NLMF indicates a deficit in acute muscular performance in unexercised muscles as a result of exercising other (including contralateral) muscle groups (see Halperin et al, 2015 for a comprehensive review).…”

Section: R a F Tmentioning

confidence: 99%

A comparison of volume-equated knee extensions to failure, or not to failure, upon rating of perceived exertion and strength adaptations

Fisher

Blossom

Steele

2016

Appl. Physiol. Nutr. Metab.

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The present study aimed to compare the effects of repetition duration-, volume-, and load-matched resistance training to muscular failure (MMF) or not to muscular failure (NMF) on maximal voluntary isometric knee extensor strength. This design also allowed testing of the efficacy of "5×5" training. Nine recreationally active males (age, 21.4 ± 1.2 years; height, 1.79 ± 0.07 m; weight, 78.4 ± 7.1 kg) performed unilateral resistance training at 80% of maximal torque at 2×/week for 6 weeks. Using their nondominant leg, participants performed 5 sets of 5 repetitions (NMF). Using their dominant leg, participants performed 25 repetitions in as few sets as possible (MMF). All repetitions were performed at a pace of 2 s concentric, 1 s isometric pause, and 2 s eccentric with a 2-min rest interval between sets. Analyses identified significant pre- to post-intervention strength increases for both MMF and NMF, with effect sizes (ESs) of 2.01 and 1.65, respectively, with no significant differences between conditions (p > 0.05). Peak and mean ratings of perceived exertion (RPEs) were significantly higher for MMF compared with NMF conditions (p < 0.0001), and a tendency for significantly higher RPE values reported for later sets for the NMF condition. Total training time per session was significantly longer for NMF compared with MMF (p < 0.001). The present study suggests that in untrained participants, resistance training NMF produces equivocally the same strength increases as training to MMF when volume-matched. However, resistance training to MMF appears to be a more time-efficient protocol and may produce greater strength gains as indicated by a larger ES.

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“…Finally, the cognitive demand required for maximal contraction has been argued to differ from that required for submaximal contraction 30) . Additionally, Matsuura et al 31) have suggested that changes in cognitive process by heat exposure alter power profiles, but not peak and mean power output, during each cycling sprint in RCS.…”

Section: Perspective For Further Researchmentioning

confidence: 99%

Possible contributions of group III/IV muscle afferent feedback to exercise performance

Matsuura

2016

JPFSM

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Exercise performance cannot be maintained indefinitely, i.e., it deteriorates progressively. Traditionally, deterioration of exercise performance has been attributed to failure of peripheral or central functions of muscle activity. However, muscle rigor (i.e., complete failure of muscle contractile function) never occurs and the muscle force exerted never decreases to zero even with sustained maximal muscle contraction. Furthermore, an increase in central motor output to skeletal limb muscles, and consequently, enhancement of exercise performance, is often observed at the end of a time trial race at which impairment of muscle contractile function is greater. These indicate that only failure of peripheral or central function of muscle activity determines exercise performance. However, recent studies have elucidated that group III/IV muscle afferent inputs to the central nervous system have an important role in the regulation or limitation of exercise performance. This article reviewed two viewpoints regarding contributions of group III/IV muscle afferent feedback to regulation of exercise performance.

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Non-local muscle fatigue: effects and possible mechanisms

Cited by 84 publications

References 101 publications

Effects of pre‐induced fatigue vs. concurrent pain on exercise tolerance, neuromuscular performance and corticospinal responses of locomotor muscles

Effects of pre‐induced fatigue vs. concurrent pain on exercise tolerance, neuromuscular performance and corticospinal responses of locomotor muscles

A comparison of volume-equated knee extensions to failure, or not to failure, upon rating of perceived exertion and strength adaptations

Possible contributions of group III/IV muscle afferent feedback to exercise performance

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