Non-Linear Reduction of Ion Currents in Cultured Cardiac Myocytes: Correlation with a Loss of T-Tubules?

Abstract

Ischemic heart disease is a common pro-arrhythmic condition characterized by hypoxia, acidosis, hyperkalemia and impaired Ca(2þ) handling. Here we investigated the ischemia responses to acute hypoxia and acidification in developing cardiomyocytes derived from neonatal rat hearts (rN-CM) or human induced pluripotent stem cells. L-type Ca(2þ) current (I Ca ) was measured