Non-linear mechanical properties and dynamic response of silicon nitride bioceramic

Du, Xiaoyu; Blugan, Gurdial; Künniger, Tina; Lee, Seunghun S.; Vladislavova, Liliya; Ferguson, Stephen J.

doi:10.1016/j.ceramint.2021.08.261

Cited by 15 publications

(7 citation statements)

References 51 publications

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“…Furthermore, the decrease in axes lengths brought about lower V and lower D . Lower density upon inclusion of B is critically important because various methods have been meticulously studied to attain lower density in bioceramics to increase implant acceptance and solubility as well as to overcome the stress shielding phenomenon which prevents favorable mechanotransduction at the bone–biomaterial interface . In this context, BcHA could perform much more efficiently in comparison to cHA.…”

Section: Discussionmentioning

confidence: 99%

Versatile-in-All-Trades: Multifunctional Boron-Doped Calcium-Deficient Hydroxyapatite Directs Immunomodulation and Regeneration

Pazarçeviren

Akbaba

Evis

et al. 2022

ACS Biomater. Sci. Eng.

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Osseointegration of implants depends on several intertwined factors: osteogenesis, angiogenesis, and immunomodulation. Lately, novel reinforcements allowing faster bonding with osseous tissue have been explored intensively. In this study, we hypothesized the use of boron as a major multifunctional ion to confer versatility to calcium-deficient hydroxyapatite (cHA) synthesized by a wet precipitation/microwave reflux method. By synthesis of boron-doped calcium-deficient hydroxyapatite (BcHA), we expected to obtain an osteoimmunomodulatory and regenerative nanoreinforcement. BcHA was found to possess a pure HA phase, a greater surface area (66.41 m 2 /g, p = 0.028), and cumulative concentrations of Ca (207.87 ± 6.90 mg/mL, p < 0.001) and B (112.70 ± 11.79 mg/mL, p < 0.001) released in comparison to cHA. Osteogenic potential of BcHA was analyzed using human fetal osteoblasts. BcHA resulted in a drastic increase in the ALP activity (1.11 ± 0.11 mmol/gDNA·min, p < 0.001), biomineralization rate, and osteogenic gene expressions compared to cHA. BcHA angiogenic potential was investigated using human umbilical cord vein endothelial cells. Significantly, the highest VEGF-A release (1111.14 ± 87.82 in 4 h, p = 0.009) and angiogenic gene expressions were obtained for BcHA-treated samples. These samples were also observed to induce a more prominent and highly branched tube network. Finally, inflammatory and inflammasome responses toward BcHA were elucidated using human monocyte-derived macrophages differentiated from THP-1s. BcHA exhibited lower CAS-1 release (50.18 ± 5.52 μg/g DNA μg/gDNA) and higher IL-10 release (126.97 ± 15.05 μg/g DNA ) than cHA. In addition, BcHA treatment led to increased expression of regenerative genes such as VEGF-A, RANKL, and BMP-2. In vitro results demonstrated that BcHA has tremendous osteogenic, angiogenic, and immunomodulatory potential to be employed as a “versatile-in-all-trades” modality in various bone tissue engineering applications.

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Section: Discussionmentioning

confidence: 99%

Versatile-in-All-Trades: Multifunctional Boron-Doped Calcium-Deficient Hydroxyapatite Directs Immunomodulation and Regeneration

Pazarçeviren

Akbaba

Evis

et al. 2022

ACS Biomater. Sci. Eng.

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“…It has been noted that the reduction of porosity in silicon nitride is frequently accompanied by an increase in mechanical properties. 49 However, the porous structure enables greater cell adhesion on the surface of silicon nitride, which maximizes the use of bioactive ions produced on the surface and promotes the rapid formation of an osteogenic microenvironment. 50,51 In various applications, the porosity and mechanical properties of silicon nitride are subject to distinct specifications.…”

Section: Molding Process Of Silicon Nitride Implants and Its Impact O...mentioning

confidence: 99%

Recent advances in the application and biological mechanism of silicon nitride osteogenic properties: a review

Liu,

Wang,

Liu

et al. 2023

Biomater. Sci.

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“…In one of our studies [ 51 ], we evaluated the correlation between mechanical properties and the porosity of Si 3 N 4 bioceramics. Our results showed that Young’s modulus and compressive strength decreased non-linearly with increasing porosity.…”

Section: Mechanical Properties Of Si 3 Nmentioning

confidence: 99%

Silicon Nitride as a Biomedical Material: An Overview

Lee

Blugan

et al. 2022

IJMS

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Silicon nitride possesses a variety of excellent properties that can be specifically designed and manufactured for different medical applications. On the one hand, silicon nitride is known to have good mechanical properties, such as high strength and fracture toughness. On the other hand, the uniqueness of the osteogenic/antibacterial dualism of silicon nitride makes it a favorable bioceramic for implants. The surface of silicon nitride can simultaneously inhibit the proliferation of bacteria while supporting the physiological activities of eukaryotic cells and promoting the healing of bone tissue. There are hardly any biomaterials that possess all these properties concurrently. Although silicon nitride has been intensively studied as a biomedical material for years, there is a paucity of comprehensive data on its properties and medical applications. To provide a comprehensive understanding of this potential cornerstone material of the medical field, this review presents scientific and technical data on silicon nitride, including its mechanical properties, osteogenic behavior, and antibacterial capabilities. In addition, this paper highlights the current and potential medical use of silicon nitride and explains the bottlenecks that need to be addressed, as well as possible solutions.

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Non-linear mechanical properties and dynamic response of silicon nitride bioceramic

Cited by 15 publications

References 51 publications

Versatile-in-All-Trades: Multifunctional Boron-Doped Calcium-Deficient Hydroxyapatite Directs Immunomodulation and Regeneration

Versatile-in-All-Trades: Multifunctional Boron-Doped Calcium-Deficient Hydroxyapatite Directs Immunomodulation and Regeneration

Recent advances in the application and biological mechanism of silicon nitride osteogenic properties: a review

Silicon Nitride as a Biomedical Material: An Overview

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