Non-linear input-output relationships in the subthalamic nucleus of Parkinson’s patients
Xiaowei Liu,
Stefanie Glowinsky,
Hodaya Abadi
et al.
Abstract:Both local field potentials (LFP) and spiking (SPK) activity in the subthalamic nucleus (STN) are related to Parkinson's disease (PD) symptoms; however, their relationship is poorly understood. We explore it by separating STN signals of 146 PD patients (308 trajectories, >25,000 recording sites) into aperiodic and periodic components and whitening these signals using their corresponding aperiodic parameters. The LFP aperiodic exponents resemble Brown noise (a = 2.20 +/- 0.40) and are significantly higher th… Show more
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