We estimate the two-loop perturbative corrections to zero-recoil matrix elements of the flavour-changing currentsc γ µ b andc γ µ γ 5 b by calculating the terms of order n f α 2 s and substituting the dependence on the number of flavours by the first coefficient of the β-function. Both for vector and axial vector currents, we find moderate twoloop corrections below 1% in magnitude. Using the Brodsky-LepageMackenzie prescription to set the scale in the order-α s corrections in the MS scheme, we obtain µ V ≃ 0.92in the two cases. These scales are sufficiently large for perturbation theory to be well-behaved. The implications of our results to the extraction of | V cb | are briefly discussed.