Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation

Abstract

A case of non-keratinizing, EBV-positive (EBER-in situ hybridization), carcinoma with adenomatous differentiation is presented. The patient is a 40 year old male with T2N2M0 disease who received standard combined chemo-and radiotherapy with complete resolution of all tumor. The tumor cells were strongly positive for low-molecular weight cytokeratins (AE1-3) and scattered cells expressed cytokeratin 20. No expression of cytokeratin 5/6, 7, p63, TTF-1, CDX2 or androgen receptor was detected. There was no evidence of recurrence or disease progression on follow-up after 19 months, which included post treatment MRI and PET-CT scans.

A rare case of intracytoplasmic mucin‐rich nasopharyngeal carcinoma

“…10 In rare conditions, NPC with adenomatous differentiation and salivary gland features also occur in the nasopharynx. 3,4 Kuo et al reported a series of salivary gland type NPCs in which mucoepidermoid carcinoma (MEC) was the most common pathology. 4 In addition, Kusafuka et al…”

“…Only a small number of studies have reported rare variants of NPC, with spindle cell, pleomorphic, and papillary types being relatively well‐known variants 2 . More recent studies have reported rare variants with reticular and myxoid patterns 3 and prominent stromal desmoplasia 10 . In rare conditions, NPC with adenomatous differentiation and salivary gland features also occur in the nasopharynx 3,4 .…”

“…In addition to these classical morphologies, NPCs may have various uncommon histological patterns 2 . Some studies report a salivary gland type and adenocarcinoma‐like NPC as uncommon variants 3–5 . However, the morphological spectrum of NPC remains to be understood.…”

“…2 Some studies report a salivary gland type and adenocarcinoma-like NPC as uncommon variants. [3][4][5] However, the morphological spectrum of NPC remains to be understood. NPC often presents with cervical lymphadenopathy, preceding the identification of the primary tumor.…”

EBV-Associated Non-keratinizing Nasopharyngeal Carcinoma with Prominent Spindled Cell and Whorling Patterns: A Previously Unreported Histological Variant in a Patient Presenting with Dermatomyositis

“…Very rarely, NPC may display a cord-like, reticular arrangement of tumor cells associated with significant myxoid substances in the stroma [2]. Another very uncommon histological pattern in NPC is adenomatous/glandular differentiation [3]. This report presents a patient with a nonkeratinizing NPC which predominantly was composed of neoplastic spindle cells which were organized into whorls, frequently around small caliber blood vessels.…”